L-(+)-Ergothioneine /CAS:497-30-3

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Ukusetshenziswa

I-Ergothioneine inezinhlelo zokusebenza eziningi kanye namathuba emakethe athembisayo ekufakweni kwezitho zomzimba, ukulondolozwa kwamaseli, imithi, ukudla neziphuzo, ukudla okusebenzayo, ukudla kwezilwane, izimonyo kanye ne-biotechnology.

Njenge-antioxidant yemvelo engenabo ubuthi enezakhiwo eziqinile zokuvikela izicubu, imelana ne-oxidation ezixazululweni zamanzi. Ngenxa yalesi sizathu, ukuhlushwa kwayo ezicutshini ezithile kungafinyelela ezingeni le-millimolar, futhi kusebenze uhlelo lokuzivikela lwe-antioxidant lweseli lomzimba.

Ihlukile kwamanye ama-antioxidants amaningi, i-ergothioneine iyakwazi ukukhipha ama-ion ensimbi esindayo futhi ivikele amangqamuzana abomvu egazi emzimbeni ekulimaleni okubangelwa ama-free radical.

I-Ergothioneine iyisithako esinamandla sokukhipha i-hypochlorous acid (HOCl). Nakuba amakhemikhali amaningi angasabela ne-hypochlorous acid, ambalwa enza lokho ngokushesha njenge-ergothioneine.

I-Alpha-1-antiproteinase inhibitor (API), njenge-elastase, isengozini enkulu ye-hypochlorous acid. Uma iqongelela emzimbeni, i-ergothioneine ingavikela ngempumelelo i-API ekungasebenzini okubangelwa yi-hypochlorous acid. Njengoba ama-neutrophils ewumthombo oyinhloko we-hypochlorous acid emzimbeni womuntu, i-ergothioneine isiza ukuvikela amangqamuzana abomvu egazi ekulimaleni okubangelwa ama-neutrophils ezindaweni ezivamile zokusebenza noma izilonda ezivuvukele.

I-Ergothioneine (efushaniswe ngokuthi i-ET noma i-EGT) iyi-amino acid yemvelo engavamile etholakala kuyo. Ngo-1909, uCharles Tanret wathola inhlanganisela eyingqayizivele equkethe i-sulfur ekristalini ngenkathi efunda isikhunta se-ergot esihlasela okusanhlamvu kwe-rye. Le thiol encibilikayo emanzini kamuva yaqanjwa ngokuthi i-ergothioneine ngemuva kwesikhunta se-ergot.

I-EGT itholakala kabanzi kumaseli amagciwane, ezitshalweni nasezilwaneni, ngamazinga aphezulu ekudleni okufana namakhowe, ubhontshisi omnyama, ubhontshisi obomvu kanye ne-oats. Njengento engokwemvelo emzimbeni womuntu, i-EGT iqoqana ngamanani aphezulu kumaseli nezicubu ezahlukahlukene, ikakhulukazi kumaseli abomvu egazi, umnkantsha wamathambo, isibindi, izinso, isidoda, kanye nelensi kanye ne-cornea yamehlo.

Ama-microorganism athile afaka phakathi i-mycobacteria angakhiqiza i-EGT, kodwa umzimba womuntu awukwazi ukuyikhiqiza ngokuzimela futhi kumele uyithole futhi uyiqongelele ngokudla.

Ngokwekhemikhali, i-ergothioneine iyi-derivative yama-amino acid aqukethe i-sulfur. I-athomu yayo ye-sulfur eqinile ibangela amandla ayo ahlukile okulwa ne-antioxidant. I-athomu ye-sulfur ibamba futhi iqede ama-free radicals, ngaleyo ndlela inciphise ukucindezeleka kwe-oxidative kanye nomonakalo kumaseli. Ngaphezu kwalokho, i-ergothioneine i-lipophilic, okwenza ikwazi ukungena emangqamuzaneni eseli futhi iveze imiphumela ngaphakathi kwamaseli, okuthuthukisa ukusebenza kwayo kwe-antioxidant.

I-Ergothioneine ayitholakali kalula. Ngaphandle kwesikhunta se-ergot, inani elincane lingatholakala nakwezinye izikhunta, amagciwane kanye nezitshalo. Noma kunjalo, abantu bayithola kakhulu ekudleni kwansuku zonke, okuhlanganisa izithako ezifana namakhowe e-golden oyster, i-ganoderma lucidum kanye ne-cordyceps.

Ukupakisha Nokuthumela

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Gcina futhi ugcine

Isikhathi sokuphila: Izinyanga ezingama-24 kusukela ngosuku lokwenziwa kwento epakishweni lokuqala elingavulwanga, igcinwe endaweni epholile neyomile kude nokukhanya kwelanga okuqondile, amanzi.
Indawo yokugcina izinto enomoya, Ukomisa okuphansi kwezinga lokushisa, Ihlukaniswe nama-oxidants, ama-acid.