L-(+)-Ergothioneine /CAS:497-30-3

kikoʻī

Hoʻohana

Loaʻa iā Ergothioneine nā noi ākea a me nā manaʻolana mākeke hoʻohiki i ka hoʻoili ʻana o nā kino, mālama ʻana i nā cell, nā lāʻau lapaʻau, nā meaʻai a me nā mea inu, nā meaʻai hana, nā meaʻai holoholona, ​​​​nā mea hoʻonani a me ka biotechnology.

Ma ke ʻano he antioxidant kūlohelohe ʻaʻohe ʻawahia me nā waiwai cytoprotective ikaika, kūpaʻa ia i ka oxidation i loko o nā hopena wai. No kēia kumu, hiki i kona hoʻohuihui ʻana i loko o kekahi mau ʻiʻo ke hiki i ka pae millimolar, a hoʻāla ia i ka ʻōnaehana pale antioxidant cellular kūlohelohe o ke kino.

ʻOkoʻa mai nā antioxidants ʻē aʻe he nui, hiki i ka ergothioneine ke chelating ions metala kaumaha a pale i nā hunaola koko ʻulaʻula i loko o ke kino mai ka pōʻino i hana ʻia e nā radical free.

He mea hoʻopau ikaika ʻo Ergothioneine i ka waikawa hypochlorous (HOCl). ʻOiai hiki i nā hui he nui ke pane me ka waikawa hypochlorous, kakaikahi ka poʻe e hana pēlā me ka wikiwiki e like me ka ergothioneine.

ʻO ka mea hoʻopaʻa Alpha-1-antiproteinase (API), e like me ka elastase, he mea maʻalahi loa ia i ka waikawa hypochlorous. Ma nā ʻano physiological, hiki i ka ergothioneine ke pale pono i ka API mai ka inactivation i hoʻokomo ʻia e ka waikawa hypochlorous. ʻOiai ʻo neutrophils ke kumu nui o ka waikawa hypochlorous i loko o ke kino o ke kanaka, kōkua ka ergothioneine i ka pale ʻana i nā hunaola koko ʻulaʻula mai ka hōʻino ʻia e nā neutrophils ma nā wahi hana maʻamau a i ʻole nā ​​​​​​ʻeha mumū.

ʻO Ergothioneine (i hoʻopōkole ʻia ʻo ET a i ʻole EGT) kahi mea i loaʻa i ka amino acid kūlohelohe kakaʻikahi. I ka makahiki 1909, ua hoʻokaʻawale ʻo Charles Tanret i kahi hui sulfur crystalline kū hoʻokahi i ka wā e aʻo ana i nā fungi ergot e hoʻopilikia ana i nā hua rai. Ua kapa ʻia kēia thiol wai-soluble ʻo ergothioneine ma hope o ka fungi ergot.

Loaʻa nui ʻia ʻo EGT i loko o nā pūnaewele microbial, nā mea kanu a me nā holoholona, ​​me nā pae kiʻekiʻe i nā meaʻai e like me nā halo, nā pīni ʻeleʻele, nā pīni ʻulaʻula a me ka oats. Ma ke ʻano he mea kūlohelohe i loko o ke kino o ke kanaka, hōʻiliʻili ʻo EGT i nā nui kiʻekiʻe i loko o nā pūnaewele a me nā ʻiʻo like ʻole, ʻoi aku hoʻi i nā hunaola koko ʻulaʻula, ka iwi iwi, ke akepaʻa, nā puʻupaʻa, ka semen, a me ka lens a me ka cornea o nā maka.

Hiki i kekahi mau microorganism e like me ka mycobacteria ke hana i ka EGT, akā ʻaʻole hiki i ke kino kanaka ke hana kūʻokoʻa a pono e loaʻa a hōʻiliʻili iā ia ma o ka ʻai ʻana i ka meaʻai.

Ma ke ʻano kemika, ʻo ka ergothioneine kahi mea i loaʻa mai nā waikawa amino i loaʻa ka sulfur. ʻO kona ʻātoma sulfur paʻa ke kumu o kona hiki ke antioxidant. Hoʻopaʻa a hoʻopau ka ʻātoma sulfur i nā radical manuahi, no laila e hōʻoluʻolu ana i ke kaumaha oxidative a me ka hōʻino ʻana i nā cell. Eia kekahi, he lipophilic ka ergothioneine, e hiki ai iā ia ke komo i loko o nā membrane cell a hoʻopuka i nā hopena i loko o nā cell, kahi e hoʻonui hou aku ai i kāna hana antioxidant.

He kakaikahi ka Ergothioneine ma ke ʻano. Ma waho aʻe o nā fungi ergot, hiki ke ʻike ʻia nā nui liʻiliʻi i loko o kekahi mau fungi, bacteria a me nā mea kanu ʻē aʻe. Eia nō naʻe, loaʻa nui i nā kānaka mai nā meaʻai o kēlā me kēia lā, me nā mea hoʻohui e like me nā halo oyster gula, ganoderma lucidum a me cordyceps.

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