Fosaprepitant dimeglumine / CAS：265121-04-8
Kufotokozera Kwachidule:
Dzina la mankhwala: Fosaprepitant dimeglumine
Mtundu:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
KAYAMBIDWE:
zofunikira
| Chinthu Choyesera | Zofunikira Zovomerezeka | Zotsatira |
| Maonekedwe | Ufa woyera kapena wopanda mtundu woyera | Ufa woyera |
| Kusungunuka | Mankhwalawa amasungunuka mosavuta m'madzi ndi methanol, koma sasungunuka mu ethanol kapena acetonitrile | Tsatirani |
| Kuzungulira kwapadera | +28.0° mpaka＋33.0°
| +31.5°
|
| Kuzindikira kwa UV | Pali kuyamwa kwakukulu pa mafunde a 210nm ndi 263nm | Tsatirani
|
| Kuzindikira kwa infrared | Mtundu wa infrared absorption spectrum uyenera kugwirizana ndi mtundu wa chinthu chofotokozera. | Tsatirani
|
| Kuzindikiritsa kwa Chromatographic | Nthawi yosungira ya nsonga yayikulu ya yankho loyesera iyenera kukhala yofanana ndi nthawi ya yankho lofotokozera | Tsatirani
|
| Alkalinity | 7.0~9.0 | 7.7 |
| Kumveka bwino kwa yankho | Ziyenera kukhala zomveka bwino; Kutseguka kulikonse komwe kwapangidwa sikumveka bwino kuposa kuimitsidwa kwa reference II | Tsatirani
|
| Zinthu zokhudzana nazo | Zonyansa A ≤ 0.15% Zonyansa B ≤ 0.1% Kusayera I3-1 ≤ 0.15% Zonyansa zina ≤ 0.10% Zonyansa zonse ≤ 1.0% | 0.08% Zosadziwika 0.04% 0.03% 0.15% |
| Enantiomeri | Osapitirira 0.15% | Zosadziwika |
| Zosungunulira zotsalira 1 | Methanol ≤3000ppm Ethanol ≤5000ppm Acetonitrile ≤410ppm Ether ≤5000ppm Acetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Zosadziwika 54ppm 2636ppm 187ppm Zosadziwika
|
| Chosungunulira chotsalira 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Kuchuluka kwa madzi | ≤2.0% | 1.4% |
| Zitsulo zolemera | Sayenera kupitirira 10 ppm | Tsatirani |
| Palladium | Osapitirira 5 ppm | Zosadziwika |
| Chloride | Siziyenera kupitirira 0.01% | Tsatirani |
| Sulfate | Siyenera kupitirira 0.1% | Tsatirani |
| Meglumine | Malinga ndi kuwerengera kwa anhydrous, kuchuluka kwa C7H17NO5 kuyenera kukhala 37.8% mpaka 39.8% | 38.5% |
| Kuyesa | Malinga ndi kuwerengera kwa anhydrous, zomwe zili mu C23H22F7N4O6P·2(C7H17NO5) iyenera kukhala 98.0% ~ 102.0% | 100.4%
|
| Endotoxin ya bakiteriya | Kuchuluka kwa endotoxin pa mg wa Fosaprepitant Dimeglumine kuyenera kukhala kochepera 0.16 EU | Tsatirani
|
| Malire a Tizilombo Tosaoneka ndi Maso | Chiwerengero chonse cha tizilombo toyambitsa matenda m'thupi sichidutsa 100 cfu, chiwerengero chonse cha nkhungu ndi yisiti sichidutsa 50 cfu pa g iliyonse ya chitsanzo choyesedwa ndipo Escherichia coli palibe. | Chiwerengero chonse cha tizilombo toyambitsa matenda: 3cfu/g Chiwerengero cha nkhungu zonse ndi yisiti zophatikizidwa:＜10cfu/g Escherichia coli: Sizikudziwika
|
| Mapeto | Chogulitsacho chikutsimikizira muyezo wa bizinesi | |
Kagwiritsidwe Ntchito
Pali mitundu itatu ya ma neurokinin receptors: NK1, NK2 ndi NK3. Pakati pawo, NK1 receptor imakhala ndi mphamvu yolumikizana kwambiri ndi P komanso kuchuluka kwa zinthu zomwe zimapezeka pakati pa kusanza kwa ubongo. Pambuyo poti NK1 receptor yalumikizana ndi P mu dongosolo lapakati la mitsempha, imayambitsa njira zingapo zoyambitsa matenda monga kusanza, nkhawa ndi mutu waching'alang'ala. Ma NK1RA monga apirpitan ndi fosapirpitan amateteza ndikuchiza CINV mwa kumangirira mosankha ku NK1 receptor. Nthawi zambiri, CINV yoopsa imakhudzana ndi ntchito ya njira ya mphamvu ya 5-HT3, pomwe CINV yochedwa imakhudzana ndi P yapakati. Chifukwa chake, poyerekeza ndi 5-HT3RA, apirpitan ndi fosapirpitan zimasonyeza zabwino zodziwikiratu pakusanza mochedwa.
Fosapirtan dimethylmeglumine ndi mankhwala oletsa neurokinin-1receptor (NK-1RA) omwe adapangidwa ndi Merck. Adayambitsidwa koyamba ku United States mu Januwale 2008. Fosarpitan dimethylmegalamine ndi mankhwala oyambira a aprepitant, mankhwala oyamba a NK-1RA. Pambuyo polowa m'thupi, amatha kusinthidwa mwachangu kukhala aprepitant ndipo amagwiritsidwa ntchito kuchipatala popewa ndikuchiza nseru ndi kusanza komwe kumachitika chifukwa chogwiritsa ntchito koyamba komanso mobwerezabwereza mankhwala apakati mpaka okwera kwambiri (kuphatikizapo cisplatin yochuluka).
Fosaprepitant dimeglumine salt (MK-0517) ndi mankhwala osungunuka m'madzi a phosphoacyl precursor a aprepitant komanso NK1 antagonist.
Kulongedza ndi Kutumiza
5kg ，25kg monga momwe makasitomala amafunira.
Ndi katundu wamba ndipo amatha kutumizidwa kudzera m'nyanja ndi mlengalenga
Sungani ndi kusunga
Nthawi yosungiramo zinthu: Miyezi 24 kuyambira tsiku lopangidwa m'maphukusi oyambirira osatsegulidwa, osungidwa pamalo ozizira komanso ouma, kutali ndi dzuwa, madzi.
Nyumba yosungiramo zinthu zopumira mpweya, Youma pang'ono, Yosiyana ndi ma oxidants, ma acid.
