Fosaprepitant dimeglumine / CAS：265121-04-8
Takaitaccen Bayani:
Sunan Samfurin: Fosaprepitant dimeglumine
Nau'i:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
TSARI:
ƙayyadewa
| Kayan Gwaji | Ka'idojin Karɓa | Sakamako |
| Bayyanar | Foda fari ko mara fari | Foda fari |
| Narkewa | Wannan samfurin yana narkewa cikin sauƙi a cikin ruwa da methanol, amma ba ya narkewa a cikin ethanol ko acetonitrile | Daidaita |
| Juyawa ta musamman | +28.0° zuwa＋33.0°
| +31.5°
|
| Gano UV | Akwai matsakaicin sha a tsawon tsayin 210nm da 263nm | Daidaita
|
| Gano Infrared | Tsarin sharar infrared ya kamata ya dace da yanayin da aka nuna a cikin umarnin | Daidaita
|
| Gano Chromatographic | Lokacin riƙewa na babban kololuwar maganin gwaji ya kamata ya yi daidai da na maganin tunani | Daidaita
|
| Alkalinci | 7.0~9.0 | 7.7 |
| Bayyanar mafita | Ya kamata a bayyana a sarari; Duk wani opalescence da aka samar bai fi na dakatarwar tunani II ba. | Daidaita
|
| Abubuwa masu alaƙa | Rashin tsafta A ≤ 0.15% Rashin tsarki B ≤ 0.1% Rashin tsarki I3-1 ≤ 0.15% Sauran ƙazanta guda ɗaya ≤ 0.10% Jimlar ƙazanta ≤ 1.0% | 0.08% Ba a gano ba 0.04% 0.03% 0.15% |
| Enantiomer | Ba ya wuce 0.15% | Ba a gano ba |
| Sauran sinadarai 1 | Methanol ≤3000ppm Ethanol ≤5000ppm Acetonitrile ≤410ppm Ether ≤5000ppm Acetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Ba a gano ba 54ppm 2636ppm 187ppm Ba a gano ba
|
| Sauran sinadarin narkewa 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Yawan ruwa | ≤2.0% | 1.4% |
| Karfe masu nauyi | Bai kamata ya wuce 10 ppm ba | Daidaita |
| Palladium | Ba ya wuce ppm biyar ba | Ba a gano ba |
| Chloride | Bai kamata ya wuce 0.01% ba | Daidaita |
| Sulfate | Bai kamata ya wuce 0.1% ba | Daidaita |
| Meglumine | Dangane da lissafin da ba shi da ruwa, abun ciki na C7H17NO5 ya kamata ya kasance tsakanin 37.8% zuwa 39.8% | Kashi 38.5% |
| Gwaji | Dangane da lissafin da ba shi da ruwa, abun ciki na C23H22F7N4O6P·2(C)7H17NO5) ya kamata ya zama 98.0% ~ 102.0% | 100.4%
|
| Endotoxin na ƙwayoyin cuta | Adadin endotoxin a kowace MG na Fosaprepitant Dimeglumine ya kamata ya zama ƙasa da 0.16 EU | Daidaita
|
| Iyakar Ƙananan Kwayoyin cuta | Jimlar adadin ƙwayoyin cuta masu amfani da iskar oxygen bai wuce 100 cfu ba, jimlar adadin ƙwayoyin cuta da yisti da aka haɗa bai wuce 50 cfu a kowace g na samfurin gwaji ba kuma babu Escherichia coli. | Jimlar ƙwayoyin cuta masu amfani da iskar oxygen: 3cfu/g Jimlar adadin molds da yis da aka haɗa:＜10cfu/g Escherichia coli: Ba a Gano Ba
|
| Kammalawa | Samfurin yana tabbatar da ingancin kamfanin | |
Amfani
Akwai nau'ikan masu karɓar neurokinin guda uku: NK1, NK2 da NK3. Daga cikinsu, mai karɓar NK1 yana da ƙarfin ɗaurewa ga abu P kuma mafi girman abun ciki a cikin tsakiyar amai na kwakwalwa. Bayan mai karɓar NK1 ya ɗaure ga abu P a cikin tsarin jijiyoyi na tsakiya, yana haifar da jerin hanyoyin cututtukan jiki kamar amai, damuwa da migraine. NK1RAs kamar apirpitan da fosapirpitan suna hana da magance CINV yadda ya kamata ta hanyar zaɓar ɗaurewa ga mai karɓar NK1. Yawanci, CINV mai tsanani yana da alaƙa da aikin hanyar makamashi ta gefe 5-HT3, yayin da jinkirin CINV yana da alaƙa da sinadarin P na tsakiya. Saboda haka, idan aka kwatanta da 5-HT3RAs, apirpitan da fosapirpitan suna nuna fa'idodi bayyanannu don jinkirin amai.
Fosapirtan dimethylmeglumine wani maganin neurokinin-1receptorant (NK-1RA) ne wanda Merck ya ƙirƙiro. An fara ƙaddamar da shi a Amurka a watan Janairun 2008. Fosarpitan dimethylmegalamine shine maganin farko na aprepitant, maganin farko na NK-1RA. Bayan shiga jiki, ana iya canza shi cikin sauri zuwa aprepitant kuma ana amfani da shi a asibiti don hana da magance tashin zuciya da amai mai tsanani ko jinkiri wanda ya faru sakamakon amfani da maganin chemotherapy na matsakaici zuwa mai yawa (gami da cisplatin mai yawan shan magani).
Gishirin Fosaprepitant dimeglumine (MK-0517) magani ne mai narkewar ruwa na phosphoacyl na aprepitant da kuma mai hana NK1.
Marufi da Jigilar Kaya
5kg, 25kg a matsayin buƙatun abokin ciniki.
Ya kasance na kayan yau da kullun kuma yana iya isar da kaya ta teku da iska
Ajiyewa da adanawa
Rayuwar shiryayye: Watanni 24 daga ranar ƙera shi a cikin marufi na asali wanda ba a buɗe ba, an adana shi a wuri mai sanyi da bushewa, ba tare da hasken rana kai tsaye ba, ko ruwa.
Ma'ajiyar iska, Busar da ƙananan zafin jiki, An raba shi da sinadarai masu guba, acid.
