Fosaprepitant dimeglumine / CAS：265121-04-8
Ibisobanuro bigufi:
Izina ry'igicuruzwa: Fosaprepitant dimeglumine
Ubwoko: ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
IMITERERE:
ibipimo
| Ikintu cy'igerageza | Ibipimo ngenderwaho byo Kwemera | Ibisubizo |
| Isura | Ifu y'umweru cyangwa iy'umweru | Ifu y'umweru |
| Gushonga | Iki gicuruzwa gishobora gushonga mu mazi no muri methanol, ariko ntigishonga muri ethanol cyangwa acetonitrile. | Guhuza |
| Guhinduranya ibintu byihariye | +28.0° kugeza＋33.0°
| +31.5°
|
| Ibimenyetso bya UV | Hari ubushobozi bwo kwinjiza ibintu ku rugero rwo hejuru ku bunini bwa 210nm na 263nm | Guhuza
|
| Ibimenyetso bya infrared | Uburyo bwo kwinjiza urumuri bwa infrared bugomba kuba bujyanye n'uburyo ibintu bikoreshwa | Guhuza
|
| Ibimenyetso bya chromatografiya | Igihe cyo kubika impera y'igisubizo cy'igerageza kigomba kuba gihuye n'igihe cy'igisubizo cy'icyitegererezo | Guhuza
|
| Ubutaka | 7.0~9.0 | 7.7 |
| Gusobanutse neza k'umuti | Bigomba kuba byumvikana neza; Ubwinshi bw'amarangamutima bukozwe ntabwo bugaragara cyane kurusha ubwo guhagarika kwitabwaho kwa kabiri. | Guhuza
|
| Ibikoresho bifitanye isano | Umwanda A ≤ 0.15% Umwanda B ≤ 0.1% Umwanda I3-1 ≤ 0.15% Indi myanda imwe ≤ 0.10% Imyanda yose hamwe ≤ 1.0% | 0.08% Ntibigaragara 0.04% 0.03% 0.15% |
| Enantiomeri | Ntibirenze 0.15% | Ntibigaragara |
| Ibisigazwa by'imiti 1 | Methanoli ≤3000ppm Ethanol ≤5000ppm Acetonitrile ≤410ppm Eteri ≤5000ppm Asetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Ntibigaragara 54ppm 2636ppm 187ppm Ntibigaragara
|
| Umuti usigaye wa 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Ibipimo by'amazi | ≤2.0% | 1.4% |
| Ibyuma biremereye | Ntibigomba kurenza 10 ppm | Guhuza |
| Palladium | Ntibirenze 5 ppm | Ntibigaragara |
| Chloride | Ntibigomba kurenza 0.01% | Guhuza |
| Sulfate | Ntibigomba kurenza 0.1% | Guhuza |
| Meglumine | Dukurikije ibarura ridafite amazi, ingano ya C7H17NO5 igomba kuba hagati ya 37.8% na 39.8% | 38.5% |
| Isuzuma | Dukurikije ibarwa ridafite amazi, ibikubiye muri C23H22F7N4O6P·2(C)7H17NO5) igomba kuba 98.0% ~ 102.0% | 100.4%
|
| Uburozi bw'ingufu za bagiteri | Ingano ya endotoxin kuri mg ya Fosaprepitant Dimeglumine igomba kuba munsi ya 0.16 EU | Guhuza
|
| Umupaka wa mikorobe | Umubare wose wa mikorobe zo mu bwoko bwa aerobic nturenze 100 cfu, umubare wose wa fungi n'umusemburo uvanze nturenze 50 cfu kuri g y'ikizamini kandi Escherichia coli ntayo ifite. | Mikorobe zose zikora kuri aerobic: 3cfu/g Umubare w'ibimera n'umusemburo byose hamwe:＜10cfu/g Escherichia coli: Ntibigaragara
|
| Umwanzuro | Ibicuruzwa byemeza amahame ngenderwaho y'ikigo | |
Imikoreshereze
Hari ubwoko butatu bw'udukingirizo twa neurokinin: NK1, NK2 na NK3. Muri two, agakingirizo ka NK1 gafite ubushobozi bukomeye bwo gufata P ndetse n'ingano nini cyane mu gice cyo kuruka mu bwonko. Nyuma yuko agakingirizo ka NK1 gafata P mu gice cyo hagati cy'imitsi, gatera urukurikirane rw'ibikorwa byo kuvura indwara nko kuruka, guhangayika no kubabara umutwe. NK1RA nka apirpitan na fosapirpitan zirinda kandi zikavura CINV mu buryo bunoze zifata NK1 receptor. Ubusanzwe, CINV ikomeye ifitanye isano n'imikorere y'inzira y'ingufu ya 5-HT3, mu gihe CINV itinze ifitanye isano n'agakingirizo ka P. Kubwibyo, ugereranije na 5-HT3RA, apirpitan na fosapirpitan bigaragaza ibyiza bigaragara byo kuruka bitinze.
Fosapirtan dimethylmeglumine ni umuti urwanya neurokinin-1receptor (NK-1RA) wakozwe na Merck. Watangiye gukoreshwa muri Leta Zunze Ubumwe za Amerika muri Mutarama 2008. Fosarpitan dimethylmegalamine ni umuti ubanziriza aprepitant, umuti wa mbere wa NK-1RA. Nyuma yo kwinjira mu mubiri, ushobora guhinduka vuba aprepitant kandi ugakoreshwa mu rwego rwo gukumira no kuvura isesemi ikabije cyangwa itinze no kuruka biterwa no gukoresha imiti igabanya ubukana kugeza ku bwinshi (harimo na cisplatin ikoreshwa ku rugero rwo hejuru).
Umunyu wa Fosaprepitant dimeglumine (MK-0517) ni umuti ushongesha mu mazi wa aprepitant ukaba n'umurwanyi wa NK1.
Gupakira no Kohereza
5kg ，25kg nk'ibyo umukiriya akeneye.
Ni iy'ibicuruzwa rusange kandi ishobora gutangwa binyuze mu nyanja no mu kirere
Bika kandi ubibike
Igihe cyo kubika: Amezi 24 uhereye igihe byakorewe mu ipaki y’umwimerere idafunguye, bibitswe ahantu hakonje kandi humutse, kure y’izuba ryinshi, amazi.
Ububiko bufite umwuka uhagije, Butuma ibintu bishya bishyuha, butandukanyijwe n'ibikomoka kuri okiside, aside.
