Fosaprepitant dimeglumine / CAS：265121-04-8
Tsananguro pfupi:
Zita rechigadzirwa: Fosaprepitant dimeglumine
Rudzi:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
MAUMBIRWO:
tsanangudzo
| Chinhu Chekuyedza | Maitiro Ekugamuchira | Mhedzisiro |
| Chitarisiko | Upfu huchena kana husina kuchena | Upfu chena |
| Kunyunguduka | Chigadzirwa ichi chinonyungudika nyore nyore mumvura uye methanol, asi hachinyungudike mu ethanol kana acetonitrile | Kutevedzera |
| Kutenderera kwakananga | +28.0° kusvika＋33.0°
| +31.5°
|
| Kuzivikanwa kweUV | Kunyudzwa kwakanyanya kunowanikwa pahurefu hwemafungu e210nm ne263nm | Kutevedzera
|
| Kuzivikanwa kweinfrared | Iyo infrared absorption spectrum inofanira kunge inoenderana ne spectrum yezvinhu zvinorehwa. | Kutevedzera
|
| Kuzivikanwa kweChromatographic | Nguva yekuchengetedza peak huru yemhinduro yekuedza inofanira kuenderana neyayo yemhinduro yekutarisa | Kutevedzera
|
| Alkalinity | 7.0~9.0 | 7.7 |
| Kujeka kwemhinduro | Zvinofanira kujeka; Chero opalescence inoburitswa haina kuoneka zvakanyanya kupfuura iyo ye reference suspension II | Kutevedzera
|
| Zvinhu zvine chekuita nazvo | Kusachena A ≤ 0.15% Kusachena B ≤ 0.1% Kusachena I3-1 ≤ 0.15% Zvimwe tsvina imwe chete ≤ 0.10% Kusvibiswa kwese ≤ 1.0% | 0.08% Hazvionekwi 0.04% 0.03% 0.15% |
| Enantiomeri | Hazvipfuure 0.15% | Hazvionekwi |
| Zvinonyungudutsa zvakasara 1 | Methanol ≤3000ppm Ethanol ≤5000ppm Acetonitrile ≤410ppm Ether ≤5000ppm Acetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Hazvionekwi 54ppm 2636ppm 187ppm Hazvionekwi
|
| Chinonyungudutsa chakasara 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Mvura yakakwana | ≤2.0% | 1.4% |
| Simbi dzinorema | Haifanirwe kudarika 10 ppm | Kutevedzera |
| Palladium | Hazvipfuure mashanu ppm | Hazvionekwi |
| Chloride | Haifanirwe kudarika 0.01% | Kutevedzera |
| Sulfate | Haifanirwe kudarika 0.1% | Kutevedzera |
| Meglumine | Zvichienderana nekuverenga kweanhydrous, huwandu hweC7H17NO5 hunofanira kuva 37.8% kusvika 39.8% | 38.5% |
| Kuyedza | Zvichienderana nekuverenga kwe anhydrous, zviri mu C23H22F7N4O6P·2(C)7H17NO5) inofanira kuva 98.0%~102.0% | 100.4%
|
| Endotoxin yebhakitiriya | Huwandu hwe endotoxin pa mg yeFosaprepitant Dimeglumine hunofanira kunge huri pasi pe 0.16 EU | Kutevedzera
|
| Muganho weMabhakitiriya | Huwandu hwese hwehutachiona hwe aerobic hahupfuuri 100 cfu, huwandu hwese hwema molds ne yeast hahupfuuri 50 cfu pa g yemuenzaniso wekuyedza uye Escherichia coli haipo. | Huwandu hwehutachiona hwe aerobic: 3cfu/g huwandu hwese hwemaforoma nembiriso zvakasanganiswa:＜10cfu/g Escherichia coli: Hazvionekwi
|
| Mhedziso | Chigadzirwa chinosimbisa mwero webhizinesi | |
Kushandiswa
Kune mhando nhatu dze neurokinin receptors: NK1, NK2 naNK3. Pakati padzo, NK1 receptor ine simba rakasimba rekusunga P uye huwandu hwakanyanya pakati pekurutsa muuropi. Mushure mekunge NK1 receptor yabatana nechinhu P mu central nervous system, inotanga maitiro akasiyana-siyana ezvirwere zvakaita sekurutsa, kuzvidya mwoyo uye migraine. NK1RA dzakadai se apirpitan ne fosapirpitan dzinodzivirira nekurapa CINV nekusarudza NK1 receptor. Kazhinji, acute CINV ine chekuita nebasa re peripheral 5-HT3 energy pathway, nepo delayed CINV ine chekuita ne central P substance. Saka, kana ichienzaniswa ne 5-HT3RAs, apirpitan ne fosapirpitan zvinoratidza zvakanakira zviri pachena pakunonoka kurutsa.
Fosapirtan dimethylmeglumine mushonga we neurokinin-1receptor antagonist (NK-1RA) wakagadzirwa neMerck. Wakatangwa kekutanga muUnited States muna Ndira 2008. Fosarpitan dimethylmegalamine mushonga unotanga kushandiswa ne aprepitant, mushonga wekutanga we NK-1RA. Mushure mekupinda mumuviri, unogona kushandurwa nekukurumidza kuita aprepitant uye unoshandiswa mukiriniki kudzivirira nekurapa kuda kurutsa kwakanyanya kana kunonoka uye kurutsa kunokonzerwa nekushandiswa kwekutanga uye kudzokorora kwe chemotherapy ine mwero kusvika yakanyanya emetogenic (kusanganisira cisplatin ine mwero).
Fosaprepitant dimeglumine salt (MK-0517) mushonga we aprepitant unonyungudika mumvura uye unodzivirira NK1.
Kurongedza uye Kutumira
5kg ，25kg sezvinodiwa nevatengi.
Ndezvezvinhu zvakajairika uye zvinogona kutumirwa negungwa nemhepo
Chengeta uye chengeta
Nguva yesherufu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa kwayo, yakachengetwa munzvimbo inotonhorera yakaoma isina chiedza chezuva, mvura.
Imba yekuchengetera zvinhu ine mhepo, Inoomesa zvinhu zvishoma, Yakaparadzaniswa nezvinokonzera makemikari, maasidhi.
