ʻO ka dimeglumine Fosaprepitant / CAS：265121-04-8
Wehewehe Pōkole:
Inoa huahana: Fosaprepitant dimeglumine
ʻAno:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
ʻANO:
kikoʻī
| Mea Hoʻāʻo | Nā Kūlana ʻAe ʻia | Hopena |
| helehelena | Pauka keʻokeʻo a keʻokeʻo paha | Pauka keʻokeʻo |
| Ka hiki ke hoʻoheheʻe ʻia | He maʻalahi ka hoʻoheheʻe ʻia o kēia huahana i ka wai a me ka methanol, akā ʻaʻole hiki ke hoʻoheheʻe ʻia i ka ethanol a i ʻole ka acetonitrile | Hoʻokō |
| Hoʻohuli kikoʻī | +28.0° a i+33.0°
| +31.5°
|
| Ka ʻike UV | Aia ka omo nui loa ma nā nalu o 210nm a me 263nm | Hoʻokō
|
| ʻIke infrared | Pono ke kūlike o ka spectrum absorption infrared me ka spectrum o ka mea kuhikuhi. | Hoʻokō
|
| Ka ʻike ʻana i ke ʻano chromatographic | Pono ka manawa paʻa o ka piko nui o ka hopena hoʻāʻo e kūlike me ka hopena kuhikuhi | Hoʻokō
|
| ʻAlakino | 7.0~9.0 | 7.7 |
| Ka moakāka o ka hopena | Pono e maopopo; ʻAʻole ʻoi aku ka ʻike ʻia o kekahi opalescence i hana ʻia ma mua o ka hoʻokuʻu kuhikuhi II | Hoʻokō
|
| Nā mea pili | Haumia A ≤ 0.15% Haumia B ≤ 0.1% Haumia I3-1 ≤ 0.15% Nā mea haumia hoʻokahi ʻē aʻe ≤ 0.10% Huina haumia ≤ 1.0% | 0.08% ʻIke ʻole ʻia 0.04% 0.03% 0.15% |
| ʻEnantiomera | ʻAʻole iʻoi aku ma mua o 0.15% | ʻIke ʻole ʻia |
| Nā mea hoʻoheheʻe koena 1 | Methanol ≤3000ppm ʻEtanola ≤5000ppm ʻAsetonitrile ≤410ppm ʻEtera ≤5000ppm ʻAsetone ≤5000ppm ʻO ka Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm ʻIke ʻole ʻia 54ppm 2636ppm 187ppm ʻIke ʻole ʻia
|
| Mea hoʻoheheʻe koena 2 | ʻO Triethylamine ≤5000ppm
| 58ppm
|
| Ka nui o ka wai | ≤2.0% | 1.4% |
| Nā metala kaumaha | ʻAʻole pono e ʻoi aku ma mua o 10 ppm | Hoʻokō |
| Paladium | ʻAʻole iʻoi aku ma mua o ʻelima ppm | ʻIke ʻole ʻia |
| Kolorida | ʻAʻole pono e ʻoi aku ma mua o 0.01% | Hoʻokō |
| Sulfate | ʻAʻole pono e ʻoi aku ma mua o 0.1% | Hoʻokō |
| Meglumine | Wahi a ka helu ʻana o ka wai ʻole, ʻo ka nui o C7H17NO5 e pono ma waena o 37.8% a me 39.8%. | 38.5% |
| Hoʻāʻo | Wahi a ka helu ʻana o ka wai ʻole, ʻo ka nui o C23H22F7N4O6P·2(C7H17NO5) pono e 98.0%~102.0% | 100.4%
|
| ʻO ka endotoxin bacteria | ʻO ka nui o ka endotoxin no kēlā me kēia mg o Fosaprepitant Dimeglumine e emi iho ma mua o 0.16 EU | Hoʻokō
|
| Palena Microbial | ʻAʻole ʻoi aku ka nui o ka helu microbial aerobic ma mua o 100 cfu, ʻaʻole ʻoi aku ka nui o ka helu o nā ʻōpala a me nā hū i hui pū ʻia ma mua o 50 cfu no kēlā me kēia g o ka hāpana hoʻāʻo a ʻaʻohe ʻo Escherichia coli. | ʻO ka huina microbial aerobic: 3cfu/g ʻo ka huina o nā ʻōpala a me nā mea hū i hui pū ʻia:＜10cfu/g ʻEscherichia coli: ʻAʻole i ʻike ʻia
|
| Hopena | Hōʻoia ka huahana i ke kūlana o ka ʻoihana | |
Hoʻohana
ʻEkolu mau ʻano like ʻole o nā mea hoʻokipa neurokinin: NK1, NK2 a me NK3. I waena o lākou, ʻo ka mea hoʻokipa NK1 ka mea ikaika loa e hoʻopaʻa i ka mea P a ʻo ka nui loa o ka mea i loko o ke kikowaena luaʻi o ka lolo. Ma hope o ka hoʻopaʻa ʻana o ka mea hoʻokipa NK1 i ka mea P i loko o ka ʻōnaehana nerve waena, hoʻomaka ia i kahi moʻo o nā kaʻina hana pathophysiological e like me ka luaʻi, ka hopohopo a me ka migraine. ʻO nā NK1RA e like me apirpitan a me fosapirpitan e pale a mālama pono iā CINV ma ke koho ʻana i ka mea hoʻokipa NK1. ʻO ka maʻamau, pili ka CINV koke i ka hana o ke ala ikehu peripheral 5-HT3, ʻoiai ʻo CINV lohi e pili ana i ka mea P waena. No laila, i hoʻohālikelike ʻia me 5-HT3RA, hōʻike ʻo apirpitan a me fosapirpitan i nā pono maopopo no ka luaʻi lohi.
ʻO Fosapirtan dimethylmeglumine kahi neurokinin-1receptorantagonist (NK-1RA) i hoʻomohala ʻia e Merck. Ua hoʻokuʻu mua ʻia ma ʻAmelika Hui Pū ʻIa i Ianuali 2008. ʻO Fosarpitan dimethylmegalamine ka lāʻau mua o ka aprepitant, ʻo ia ka lāʻau NK-1RA mua. Ma hope o ke komo ʻana i ke kino, hiki ke hoʻololi koke ʻia i aprepitant a hoʻohana ʻia i loko o ke ʻano lapaʻau e pale a mālama i ka nausea a me ka luaʻi koke a lohi paha i hoʻokumu ʻia e ka hoʻohana mua a me ka hana hou ʻana o ka chemotherapy emetogenic waena a kiʻekiʻe (me ka cisplatin kiʻekiʻe).
ʻO ka paʻakai dimeglumine Fosaprepitant (MK-0517) kahi lāʻau lapaʻau phosphoacyl precursor wai o aprepitant a me kahi antagonist NK1.
ʻŌpala a me ka Hoʻouna ʻana
5kg, 25kg e like me nā koi a ka mea kūʻai aku.
No nā waiwai maʻamau a hiki ke hāʻawi ma ke kai a me ka lewa
Mālama a me ka mālama ʻana
Ola papa: 24 mahina mai ka lā i hana ʻia ai i loko o ka pahu i wehe ʻole ʻia mua i mālama ʻia i kahi maloʻo a me kahi anuanu, mai ka lā pololei, ka wai.
Hale kūʻai ea, hoʻomaloʻo wela haʻahaʻa, hoʻokaʻawale ʻia mai nā mea hoʻomake a me nā waikawa.
