Fosaprepitant dimeglumine / CAS: 265121-04-8
Sharaxaad Gaaban:
Magaca badeecada: Fosaprepitant dimeglumine
Nooca:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
QAAB-DHISMEEDKA:
qeexitaan
| Shayga Tijaabada | Shuruudaha Aqbalaadda | Natiijo |
| Muuqaalka | Budada cad ama aan cadayn | Budada cad |
| Milmida | Badeecadani si fudud ayay ugu milmi kartaa biyaha iyo methanol, laakiin kuma milmi karto ethanol ama acetonitrile. | U hoggaansan |
| Wareeg gaar ah | +28.0° ilaa＋33.0°
| +31.5°
|
| Aqoonsiga UV-ga | Waxaa jira nuugista ugu badan ee hirarka 210nm iyo 263nm | U hoggaansan
|
| Aqoonsiga Infrared-ka | Noocyada nuugista infrared-ka waa inay la jaanqaadaan noocyada walxaha tixraaca | U hoggaansan
|
| Aqoonsiga koromogaraafka | Waqtiga haynta ee ugu sarreeya xalka tijaabada waa inuu la jaanqaadaa kan xalka tixraaca | U hoggaansan
|
| Alkalinity | 7.0~9.0 | 7.7 |
| Hufnaanta xalka | Waa inay caddahay; Opalescence kasta oo la soo saaro kama muuqato mid ka badan kan joojinta tixraaca II | U hoggaansan
|
| Walxaha la xiriira | Nadaafad A ≤ 0.15% Nadaafad B ≤ 0.1% Nadaafad I3-1 ≤ 0.15% Waxyaabaha kale ee wasakhda ah ≤ 0.10% Wadarta wasakhda ≤ 1.0% | 0.08% Lama ogaan 0.04% 0.03% 0.15% |
| Enantiomer | Aan ka badnayn 0.15% | Lama ogaan |
| Dareeraha haray 1 | Methanol ≤3000ppm Etanool ≤5000ppm Acetonitrile ≤410ppm Ether ≤5000ppm Asetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Lama ogaan 54ppm 2636ppm 187ppm Lama ogaan
|
| Dareeraha haraaga ah 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Biyaha ku jira | ≤2.0% | 1.4% |
| Biraha culus | Waa inaysan ka badnaan 10 ppm | U hoggaansan |
| Palladium | Aan ka badnayn shan ppm | Lama ogaan |
| Koloriin | Waa inaysan ka badnaan 0.01% | U hoggaansan |
| Sulfate | Waa inaysan ka badnaan 0.1% | U hoggaansan |
| Meglumine | Sida ku cad xisaabinta aan biyaha lahayn, waxa ku jira C7H17NO5 waa inuu ahaadaa 37.8% ilaa 39.8% | 38.5% |
| Baaritaan | Sida laga soo xigtay xisaabinta aan biyaha lahayn, waxa ku jira C23H22F7N4O6P·2(C)7H17NO5) waa inuu ahaadaa 98.0% ~ 102.0% | 100.4%
|
| Endotoxin bakteeriya ah | Cadadka endotoxin ee mgkiiba Fosaprepitant Dimeglumine waa inuu ka yaraadaa 0.16 EU | U hoggaansan
|
| Xadka Microbial-ka | Wadarta tirada microbial-ka hawada lagu shubo kama badna 100 cfu, tirada guud ee caaryada iyo khamiirka isku dhafan kama badna 50 cfu halkii g ee muunadda tijaabada, Escherichia coli-na ma jirto. | Wadarta guud ee microbial-ka aerobic-ga: 3cfu/g Tirada guud ee caaryada iyo khamiirka isku dhafan:＜10cfu/g Escherichia coli: Lama ogaan
|
| Gunaanad | Badeecadu waxay xaqiijinaysaa heerka ganacsiga | |
Isticmaalka
Waxaa jira saddex nooc oo ah soo-dhoweeyayaasha neurokinin: NK1, NK2 iyo NK3. Kuwaas waxaa ka mid ah, soo-dhoweeyaha NK1 wuxuu leeyahay awoodda ugu xooggan ee isku xidhka walaxda P iyo waxa ugu sarreeya ee ku jira xarunta matagga maskaxda. Ka dib marka soo-dhoweeyaha NK1 uu ku xidhmo walaxda P ee nidaamka neerfaha dhexe, waxay kicisaa taxane ah hababka cudurka sida matag, walwal iyo madax-xanuun. NK1RAs sida apirpitan iyo fosapirpitan si wax ku ool ah ayay uga hortagaan oo u daaweeyaan CINV iyagoo si xushmad leh ugu xidha soo-dhoweeyaha NK1. Badanaa, CINV-ga daran wuxuu la xiriiraa dhaqdhaqaaqa marinnada tamarta ee 5-HT3 ee ku wareegsan, halka CINV-ga dib u dhacay uu la xiriiro walaxda P ee dhexe. Sidaa darteed, marka la barbar dhigo 5-HT3RAs, apirpitan iyo fosapirpitan waxay muujinayaan faa'iidooyin cad oo loogu talagalay matagga dib u dhaca.
Fosapirtan dimethylmeglumine waa daawo neurokinin-1receptorantagonist (NK-1RA) oo ay samaysay Merck. Waxaa markii ugu horreysay laga bilaabay Mareykanka bishii Janaayo 2008. Fosarpitan dimethylmegalamine waa daawada horudhaca ah ee aprepitant, oo ah daawada ugu horreysa ee NK-1RA. Ka dib marka la galo jirka, si dhakhso ah ayaa loogu beddeli karaa aprepitant waxaana si caafimaad ahaan loo isticmaalaa si looga hortago loona daweeyo lallabbo iyo matag degdeg ah ama dib u dhac ah oo ay keento isticmaalka bilowga ah iyo kan soo noqnoqda ee kiimoterabiga ee dhexdhexaadka ah ilaa kan sare (oo ay ku jiraan cisplatin oo qiyaas sare leh).
Cusbada Fosaprepitant dimeglumine (MK-0517) waa daawo fosfoacyl ah oo biyo ku milma oo ka mid ah aprepitant iyo NK1 antagonist.
Baakadeynta iyo Rarista
5kg, 25kg sida shuruudaha macaamiisha.
Waxay ka tirsan tahay alaabta caadiga ah waxayna ku keeni kartaa bad iyo cirka
Hayso oo kaydi
Muddada shelf-ka: 24 bilood laga bilaabo taariikhda la sameeyay ee baakadaha asalka ah ee aan la furin lagu kaydiyay meel qabow oo qalalan oo ka fog iftiinka qorraxda tooska ah, biyaha.
Bakhaar hawo leh, Qallajin heerkul hooseeya, Ka soocan oksaydhiyeyaasha, asiidhyada.
