Fosaprepitant dimeglumine / CAS：265121-04-8
Whakaahuatanga Poto:
Ingoa hua: Fosaprepitant dimeglumine
Momo:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
HANGANGA:
whakatakotoranga
| Tuemi Whakamātautau | Ngā Paearu Whakaae | Hua |
| Āhua | Paura mā, paura mā-parauri rānei | Paura mā |
| Te wairewatanga | He ngāwari te wairewa o tēnei hua ki te wai me te methanol, engari kāore e wairewa ki te ethanol, ki te acetonitrile rānei | Whakaū |
| Hurihanga motuhake | +28.0° ki+33.0°
| +31.5°
|
| Te tautuhi UV | Ka taea te mimiti rawa i ngā roangaru o te 210nm me te 263nm | Whakaū
|
| Te tautuhi infrared | Me rite te whānuitanga mimiti o te hihi whero ki te whānuitanga o te matū tohutoro. | Whakaū
|
| Te tautuhi ira-ira | Me rite te wā pupuri o te tihi matua o te otinga whakamātautau ki te wā pupuri o te otinga tohutoro. | Whakaū
|
| Te kawakore | 7.0~9.0 | 7.7 |
| Te mārama o te otinga | Me mārama; Ko te opalescence e puta ana kāore e kitea nuitia atu i te o te whakatārewatanga tohutoro II | Whakaū
|
| Ngā matū e pā ana | Parakore A ≤ 0.15% Parakore B ≤ 0.1% Parakore I3-1 ≤ 0.15% Ētahi atu poke takitahi ≤ 0.10% Ngā poke katoa ≤ 1.0% | 0.08% Kāore i kitea 0.04% 0.03% 0.15% |
| Enantiomera | Kāore e neke atu i te 0.15% | Kāore i kitea |
| Ngā whakarewa toenga 1 | Mētanora ≤3000ppm Etanora ≤5000ppm Acetonitrile ≤410ppm Etera ≤5000ppm Āketona ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Kāore i kitea 54ppm 2636ppm 187ppm Kāore i kitea
|
| Te toenga whakarewa 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Te nui o te wai | ≤2.0% | 1.4% |
| Ngā konganuku taumaha | Kaua e neke atu i te 10 ppm | Whakaū |
| Paratiuma | Kaua e neke atu i te rima ppm | Kāore i kitea |
| Pūhaumāota | Kaua e neke ake i te 0.01% | Whakaū |
| te whanariki | Kaua e neke ake i te 0.1% | Whakaū |
| Meglumine | E ai ki te tātaitanga waikore, ko te ihirangi o te C7H17NO5 me 37.8% ki te 39.8% | 38.5% |
| Whakamātautau | E ai ki te tātaitanga waikore, ko te ihirangi o te C23H22F7N4O6P·2(C7H17NO5) me 98.0%~102.0% | 100.4%
|
| Te endotoxin huakita | Ko te nui o te endotoxin mō ia mg o te Fosaprepitant Dimeglumine me iti iho i te 0.16 EU | Whakaū
|
| Tepe o te moroiti | Kāore te tapeke o ngā moroiti āerobic e neke atu i te 100 cfu, kāore te tapeke o ngā pokepokea ai me ngā rewena e neke atu i te 50 cfu mō ia karamu o te tauira whakamātautau, ā, kāore he Escherichia coli. | Ko te tapeke o ngā moroiti hauropi: 3cfu/g te tapeke o ngā pokepokea ai me ngā rewena i whakakotahihia:＜10cfu/g Escherichia coli: Kāore i kitea
|
| Whakamutunga | Ka whakaū te hua i te paerewa umanga | |
Whakamahinga
E toru ngā momo momo kaiwhakawhiwhi neurokinin: NK1, NK2 me NK3. I roto i ēnei, ko te kaiwhakawhiwhi NK1 te mea tino kaha ki te here ki te matū P, ā, ko te nui rawa o te ihirangi kei roto i te pokapū ruaki o te roro. I muri i te herenga o te kaiwhakawhiwhi NK1 ki te matū P i roto i te pūnaha io matua, ka tīmatahia he raupapa o ngā tukanga pathophysiological pērā i te ruaki, te manukanuka me te migraine. Ko ngā NK1RA pērā i te apirpitan me te fosapirpitan ka ārai me te rongoā i te CINV mā te herea whiriwhiri ki te kaiwhakawhiwhi NK1. I te nuinga o te wā, ko te CINV ūkui e pā ana ki te mahi o te ara pūngao 5-HT3 ā-taha, ko te CINV whakaroa e pā ana ki te matū P matua. Nō reira, ki te whakatauritea ki ngā 5-HT3RA, he mārama ngā painga o te apirpitan me te fosapirpitan mō te ruaki whakaroa.
Ko te Fosapirtan dimethylmeglumine he neurokinin-1receptor antagonist (NK-1RA) i whakawhanakehia e Merck. I whakarewahia tuatahitia ki te United States i te Hanuere 2008. Ko te Fosarpitan dimethylmegalamine te rongoā matua o te aprepitant, te rongoā NK-1RA tuatahi. I muri i te urunga ki te tinana, ka taea te huri tere hei aprepitant, ā, ka whakamahia haumanu hei ārai me te rongoā i te whakapairuaki me te ruaki ohorere, whakaroa rānei i puta mai i te whakamahinga tuatahi me te whakamahi tonu o te chemotherapy emetogenic reo-rahi ki te nui (tae atu ki te cisplatin nui-horopeta).
Ko te tote dimeglumine Fosaprepitant (MK-0517) he rongoā phosphoacyl precursor wairewa o te aprepitant me te NK1 antagonist.
Te Tākai me te Tukunga
5kg, 25kg e ai ki ngā whakaritenga a te kiritaki.
Nō ngā taonga noa, ā, ka taea te tuku mā te moana me te rangi
Te pupuri me te rokiroki
Te roa o te oranga: 24 marama mai i te rā i hangaia ai, i roto i te takai taketake kāore anō kia whakatuwheratia, rongoatia ki te wāhi matao, maroke, ā, kāore e taea te ārai i te rā tika, i te wai rānei.
Whare putunga hauhautanga, Whakamaroke pāmahana iti, Wehea mai i ngā waikura me ngā waikawa.
