Fosaprepitant dimeglumine / CAS: 265121-04-8
Nkọwa Dị Mkpirikpi:
Aha ngwaahịa: Fosaprepitant dimeglumine
Ụdị:ZA-N
CAS: 265121-04-8
MF:C30H39F7N5O11P
MW: 809.63
ỤDỊ:
nkọwapụta
| Ihe Nnwale | Usoro Nnabata | Nsonaazụ |
| Ọdịdị | Ntụ ntụ ọcha ma ọ bụ nke na-acha ọcha | Ntụ ntụ ọcha |
| Mmiri na-agbaze | Ngwaahịa a na-agbaze ngwa ngwa na mmiri na methanol, mana ọ naghị agbaze na ethanol ma ọ bụ acetonitrile | Kwekọrịta |
| Mgbanwe kpọmkwem | +28.0° ruo＋33.0°
| +31.5°
|
| Nchọpụta UV | Enwere ike itinye oke mmịpụta na ogologo ebili mmiri nke 210nm na 263nm | Kwekọrịta
|
| Nchọpụta infrared | Usoro mmịpụta infrared kwesịrị ịdị ka ụkpụrụ nke ihe ntụaka ahụ si dị | Kwekọrịta
|
| Nchọpụta kromatografik | Oge nchekwa nke isi ihe ngwọta ule kwesịrị ịdị ka nke ngwọta ntụaka | Kwekọrịta
|
| Alkalinity | 7.0~9.0 | 7.7 |
| Ihe ngwọta doro anya | Kwesịrị ka o doo anya; Opalescence ọ bụla e mepụtara anaghị apụta ìhè karịa nke ntụaka nkwụsịtụ II | Kwekọrịta
|
| Ihe ndị metụtara ya | Adịghị ọcha A ≤ 0.15% Adịghị ọcha B ≤ 0.1% Adịghị ọcha I3-1 ≤ 0.15% Ihe ndị ọzọ na-adịghị ọcha otu otu ≤ 0.10% Ihe ruru unyi niile ≤ 1.0% | 0.08% Achọpụtaghị 0.04% 0.03% 0.15% |
| Enantiomer | Agaghị agafe 0.15% | Achọpụtaghị |
| Ihe mgbaze fọdụrụnụ 1 | Methanol ≤3000ppm Ethanol ≤5000ppm Acetonitrile ≤410ppm Ether ≤5000ppm Acetone ≤5000ppm Methyl tert butyl ether ≤5000ppm Toluene ≤890ppm
| 1667ppm 92ppm Achọpụtaghị 54ppm 2636ppm 187ppm Achọpụtaghị
|
| Ihe mgbaze fọdụrụ 2 | Triethylamine ≤5000ppm
| 58ppm
|
| Mmiri dị n'ime ya | ≤2.0% | 1.4% |
| Ọla dị arọ | Agaghị agafe 10 ppm | Kwekọrịta |
| Palladium | Agaghị agafe ppm ise | Achọpụtaghị |
| Chloride | O kwesịghị ịgafe 0.01% | Kwekọrịta |
| Sọlfat | O kwesịghị ịgafe 0.1% | Kwekọrịta |
| Meglumine | Dịka ngụkọ anhydrous si kwuo, ọdịnaya nke C7H17NO5 kwesịrị ịdị site na 37.8% ruo 39.8% | 38.5% |
| Nnwale | Dịka ngụkọ anhydrous si dị, ọdịnaya nke C23H22F7N4O6P·2(C)7H17NO5) kwesịrị ịdị 98.0% ~ 102.0% | 100.4%
|
| Endotoxin nje bacteria | Ọnụọgụ endotoxin kwa mg nke Fosaprepitant Dimeglumine kwesịrị ịbụ ihe na-erughị 0.16 EU | Kwekọrịta
|
| Oke nje | Ọnụọgụ nje bacteria aerobic niile akarịghị 100 cfu, mkpokọta ebu na yist ejikọtaghị ọnụ abụghị ihe karịrị 50 cfu kwa g nke ihe nlele nnwale, Escherichia coli adịghịkwa. | Mkpokọta nje bacteria aerobic: 3cfu/g mkpokọta ebu na yist jikọtara ọnụ:＜10cfu/g Escherichia coli: Achọpụtaghị
|
| Mmechi | Ngwaahịa na-akwado ọkọlọtọ ụlọ ọrụ | |
Ojiji
E nwere ụdị atọ nke ndị na-anabata neurokinin: NK1, NK2 na NK3. N'ime ha, onye na-anabata NK1 nwere ike ijikọ ihe P na ọdịnaya kachasị elu n'etiti ọgbụgbọ nke ụbụrụ. Mgbe onye na-anabata NK1 jikọtara na ihe P na sistemụ akwara etiti, ọ na-akpali usoro usoro pathophysiological dị ka ịgbọ agbọ, nchekasị na migraine. NK1RA dị ka apirpitan na fosapirpitan na-egbochi ma gwọọ CINV nke ọma site na ijikọta na onye na-anabata NK1. Ọtụtụ mgbe, CINV dị oke njọ metụtara ọrụ nke ụzọ ike 5-HT3 dị n'akụkụ, ebe CINV na-egbu oge metụtara ihe P dị n'etiti. Ya mere, ma e jiri ya tụnyere 5-HT3RAs, apirpitan na fosapirpitan na-egosi uru doro anya maka ịgbọ agbọ.
Fosapirtan dimethylmeglumine bụ ọgwụ neurokinin-1receptorantagonist (NK-1RA) nke Merck mepụtara. E wepụtara ya na United States na Jenụwarị 2008. Fosarpitan dimethylmegalamine bụ ọgwụ mbụ nke aprepitant, ọgwụ mbụ NK-1RA. Mgbe ọ banyere n'ahụ, enwere ike ịgbanwe ya ngwa ngwa ka ọ bụrụ aprepitant ma jiri ya mee ihe n'ụlọ ọgwụ iji gbochie ma gwọọ ọgbụgbọ na ọgbụgbọ na-egbu oge ma ọ bụ nke na-egbu oge nke ejiri chemotherapy emetogenic na-eme ihe ugboro ugboro na nke dị elu (gụnyere cisplatin dị elu).
Nnu Fosaprepitant dimeglumine (MK-0517) bụ ọgwụ phosphoacyl nke a na-agbaze na mmiri nke aprepitant na onye na-emegide NK1.
Nkwakọ ngwaahịa na Mbupu
5kg, 25kg dị ka ihe ndị ahịa chọrọ.
Ọ bụ nke ngwongwo nkịtị ma nwee ike ibuga ya site n'oké osimiri na ikuku
Debe ma chekwaa
Ndụ nchekwa: ọnwa 24 site na ụbọchị emepụtara ya na ngwugwu mbụ e meghebeghị emepe echekwara n'ebe dị jụụ na kpọrọ nkụ nke na-anaghị anwụ kpọmkwem, mmiri.
Ụlọ nkwakọba ihe ikuku, Ọkụ dị ala, Nkewapụrụ na ihe ndị na-eme ka oxidants, asịd.
