I-Glutathione CAS: 70-18-8
iinkcukacha
| Into | Iinkcukacha |
| Inkangeleko | Umgubo omhlophe wekristale |
| Uvavanyo | ≥98.0% |
| Ukujikeleza okubonakalayo | -15.5—-17.5 |
| Ilahleko yokomisa | ≤0.5 |
| Umxholo wothuthu | ≤0.1 |
| Iintsimbi ezinzima | ≤20 |
| I-Arsenic | ≤2 |
Ukusetyenziswa
Ubunzima bemolekyuli ye-glutathione yi-307.33, kunye nendawo yokunyibilika ye-189-193℃ (ukubola). Ikristale ayinambala, ibonakala, incinci kwaye ikwi-columnar, kwaye i-isoelectric point yi-5.93. Iyanyibilika emanzini, inyibilikise utywala, i-ammonia engamanzi kunye ne-methylformamide, kodwa ayinyibiliki kwi-alcohol, i-ether kunye ne-acetone. Yi-GSH kuphela enomsebenzi we-physiological kwizinto eziphilayo, ngelixa i-GSSG kufuneka incitshiswe ngaphambi kokuba ikwazi ukwenza imisebenzi yayo ebalulekileyo ye-physiological. I-GSH ayilula ukuyigcina phantsi komsebenzi wamanzi amaninzi. Kuphela ngokulawula umsebenzi wamanzi ongaphantsi kwe-0.3 apho ingagcinwa ngokuzinzileyo ixesha elide. Izifundo zibonise ukuba kwisisombululo samanzi se-vitamin C esine-GSH (pH3.3), ngenxa yesiphumo esinamandla sokunciphisa i-vitamin C, i-GSH kwisisombululo ayizukuxutywa kwi-GSSG, kodwa izinga layo lokubola liyakhawuleza. I-GSSG ekhoyo kwisisombululo samanzi se-vitamin C ayizukuguqulwa ibe yi-GSH kwaye inozinzo oluhle lokugcinwa. Ngaphezu koko, i-GSSG eginywe ngomlomo inokwehliswa ibe yi-GSH kwinxalenye ephezulu yamathumbu amancinci. Ifunxwa kumphezulu weeseli ze-epithelial zamathumbu amancinci ngesenzo se-γ-GTP (ebolisa i-GSH ibe yi-glutamic acid kunye ne-Cys-Gly) kunye ne-dipeptidase, kwaye inokwenza imisebenzi yayo ebalulekileyo yomzimba.
I-glutathione encitshisiweyo yi-peptide encinci yemolekyuli ekhoyo kakhulu kwizinto eziphilayo, ingakumbi kwiiseli zesibindi. Inemisebenzi yokukhusela i-membrane yeseli yesibindi, ukukhuthaza umsebenzi wee-enzyme zesibindi, kunye nokudibanisa neekhemikhali ezininzi ezinobuthi ukuze idlale indima yokukhupha ubuthi emzimbeni. Inefuthe elihle kakhulu lokunyanga ukwenzakala kwesibindi okubangelwa zizizathu ezahlukeneyo ezifana nokutyhefwa ziziyobisi kunye nokutyhefwa ziziyobisi, kunye nezifo ezifana ne-cirrhosis yesibindi.
Inemisebenzi efana nokulwa ne-oxidation, ukususa ii-free radicals, ukukhupha ubuthi emzimbeni, ukomeleza amasosha omzimba, ukulibazisa ukuguga, ukulwa nomhlaza kunye nokuxhathisa umonakalo wemitha.
I-Glutathione ingasetyenziswa njenge-reagent ye-biochemical kunye ne-antidote, ikakhulu kunyango lwetyhefu evela kwiintsimbi ezinzima, i-acrylonitrile, ii-fluoride, i-carbon monoxide kunye nezinyibilikisi ze-organic, njl.
Ii-antioxidants zendalo ezidlala indima ebalulekileyo ekunciphiseni iintlobo zeoksijini ezisabelayo ezenziwe ngexesha le-metabolism yeseli kunye nokuphefumla ngequbuliso. I-Glutathione-S-transferase ikhuthaza ukwenziwa kwe-glutathione sulfide kunye nee-heteroorganisms, ii-leukotrienes kunye nezinye iimolekyuli ezineendawo ze-electrophilic. I-Glutathione ikwadala ii-disulfide bonds kunye nee-cysteine residues kwiiproteni. Ngale ndlela, inokuba nefuthe elingaqhelekanga lokunciphisa ukusebenza kwee-arhente zokulwa nomhlaza.
Ukupakishwa kunye nokuthunyelwa
25KG/Idrama okanye ngokweemfuno zomthengi.
Yeyokwempahla eqhelekileyo kwaye inokuhanjiswa ngolwandle nangomoya
Gcina kwaye ugcine
Ixesha lokuphelelwa: Iinyanga ezingama-24 ukususela kumhla wokwenziwa kwayo kwiphakheji yokuqala engavulwanga igcinwe kwindawo epholileyo neyomileyo kude nelanga elithe ngqo, amanzi.
Indawo yokugcina umoya, Ukomisa kubushushu obuphantsi, Yahlulwe kwii-oxidants, ii-asidi.
