I-Glutathione CAS: 70-18-8
incazelo
| Into | Imininingwane |
| Ukubukeka | Impuphu emhlophe ekristalu |
| Ukuhlolwa | ≥98.0% |
| Ukujikeleza okubonakalayo | -15.5—-17.5 |
| Ukulahlekelwa ekomiseni | ≤0.5 |
| Okuqukethwe komlotha | ≤0.1 |
| Izinsimbi ezisindayo | ≤20 |
| I-Arsenic | ≤2 |
Ukusetshenziswa
Isisindo sama-molecule e-glutathione singama-307.33, kanye nephuzu lokuncibilika elingu-189-193℃ (ukubola). Ikristalu ayinambala, isobala, incane futhi i-columnar, kanti iphuzu le-isoelectric lingu-5.93. Liyancibilika emanzini, lincibilikisa utshwala, i-ammonia ewuketshezi kanye ne-methylformamide, kodwa alincibiliki kotshwala, i-ether kanye ne-acetone. I-GSH kuphela enomsebenzi womzimba ezintweni eziphilayo, kuyilapho i-GSSG idinga ukuncishiswa ngaphambi kokuba ikwazi ukwenza imisebenzi yayo ebalulekile yomzimba. I-GSH akulula ukuyigcina ngaphansi komsebenzi wamanzi amaningi. Kuphela ngokulawula umsebenzi wamanzi ongaphansi kuka-0.3 lapho ingagcinwa khona isikhathi eside. Izifundo zikhombisile ukuthi esixazululweni samanzi se-vitamin C esiqukethe i-GSH (pH3.3), ngenxa yomphumela onamandla wokunciphisa we-vitamin C, i-GSH esixazululweni ngeke i-oxidized ibe yi-GSSG, kodwa izinga layo lokubola liyashesha. I-GSSG ekhona esixazululweni samanzi se-vitamin C ngeke iguqulwe ibe yi-GSH futhi inokuqina okuhle kokulondolozwa. Ngaphezu kwalokho, i-GSSG egwinywe ngomlomo ingancishiswa ibe yi-GSH engxenyeni engenhla yamathumbu amancane. Imuncwa ebusweni bamaseli amancane e-epithelial ngokusebenzisa isenzo se-γ-GTP (esibolisa i-GSH ibe yi-glutamic acid kanye ne-Cys-Gly) kanye ne-dipeptidase, futhi ingasebenzisa imisebenzi yayo ebalulekile yomzimba.
I-glutathione encishisiwe iyi-peptide encane yama-molecule etholakala kakhulu ezintweni eziphilayo, ikakhulukazi emangqamuzaneni esibindi. Inemisebenzi yokuvikela ulwelwesi lwamaseli esibindi, ukukhuthaza umsebenzi wama-enzyme esibindi, nokuhlanganisa namakhemikhali amaningi anobuthi ukuze idlale indima yokukhipha ubuthi emzimbeni. Inethonya elihle kakhulu lokwelapha ekulimaleni kwesibindi okubangelwa yizizathu ezahlukahlukene ezifana nobuthi bezidakamizwa kanye nobuthi botshwala, kanye nezifo ezifana ne-cirrhosis yesibindi.
Inemisebenzi efana nokulwa nokubola kwamangqamuzana, ukususa ama-free radical, ukususa ubuthi emzimbeni, ukuthuthukisa amasosha omzimba, ukubambezela ukuguga, ukulwa nomdlavuza kanye nokumelana nokulimala kwemisebe.
I-Glutathione ingasetshenziswa njenge-reagent yamakhemikhali kanye ne-antidote, ikakhulukazi ekwelapheni ubuthi obuvela ezinsimbi ezisindayo, i-acrylonitrile, i-fluoride, i-carbon monoxide kanye nezinyibilikisi eziphilayo, njll.
Ama-antioxidants angokwemvelo adlala indima ebalulekile ekunciphiseni izinhlobo ze-oxygen ezisebenzayo ezakhiwe ngesikhathi sokusebenza kweseli kanye nokuphefumula okungazelelwe. I-Glutathione -S-transferase ikhuthaza ukwakheka kwe-glutathione sulfide ene-heteroorganisms, ama-leukotrienes namanye ama-molecule anezikhungo ze-electrophilic. I-Glutathione iphinde yakhe izibopho ze-disulfide nama-cysteine residues kumaprotheni. Ngalezi zindlela, ingaba nomphumela ongavamile wokunciphisa ukusebenza kahle kwama-anti-cancer agents.
Ukupakisha Nokuthumela
25KG/Isigubhu noma ngokwezidingo zamakhasimende.
Kungokwempahla evamile futhi kungathunyelwa ngolwandle nangomoya
Gcina futhi ugcine
Isikhathi sokuphila: Izinyanga ezingama-24 kusukela ngosuku lokwenziwa kwento epakishweni lokuqala elingavulwanga, igcinwe endaweni epholile neyomile kude nokukhanya kwelanga okuqondile, amanzi.
Indawo yokugcina izinto enomoya, Ukomisa okuphansi kwezinga lokushisa, Ihlukaniswe nama-oxidants, ama-acid.
