I-Nicotinamide/CAS:98-92-0
Incazelo emfushane:
Igama lomkhiqizo: I-Nicotinamide
Uhlobo:ZA-N
I-CAS:98-92-0
MF:C6H6N2O
I-MW: 122.12
ISAKHIWO:
Ubuningi: 1.40
iphuzu lokuncibilika: 182 °C
I-Niacinamide iyi-crystal emhlophe efana nenaliti noma i-crystalline powder, ayinaphunga noma inephunga kancane, inokunambitheka okubabayo kancane. Ubuningi bayo obuhlobene bungu-1.4, kanti iphuzu layo lokuncibilika lingu-129-131℃. I-1g yalo mkhiqizo ingancibilikiswa ku-1mL yamanzi, i-1.5mL ye-ethanol, noma i-10mL ye-glycerol, kodwa hhayi ku-ether. I-pH yesisombululo samanzi esingu-10% ingu-6.5-7.5. Ine-hygroscopicity ebuthakathaka. Izinzile, imelana nama-acid, ama-alkali, kanye namazinga okushisa aphezulu. Izinzile ekukhanyeni nasekushiseni emoyeni owomile, kodwa uma ishiswa ezixazululweni ze-alkaline noma ze-acidic, yakha i-nicotinic acid. I-LD50 yomlomo kumagundane ingu-2.5-3.5g/kg, futhi inani le-ADI alicacisiwe ngokuqondile (ECC, 1990).
incazelo
| IZINTO | IZINHLOBO | ISIVIVINYO UMPHUMELA |
| Ukubukeka | Impuphu emhlophe ekristalu | Imithetho |
| Ukuncibilika | Incibilika kalula emanzini kanye nase-ethanol engenamanzi, incibilika kancane e-methylene chloride | Imithetho |
|
Ukuhlonza | A: Ukumuncwa kwe-infrared | Imithetho |
| B: Ukumuncwa kwe-Ultraviolet. isilinganiso se-A245/A262 singu-0.63-0.67 | 0.66 | |
| C. I-chromatogrzphy enezingqimba ezincane | Imithetho | |
| Ukuhlolwa (%) | 99.0~101.0 | 100.1 |
| Uhla lokuncibilika (□) | 128~131 | 128.7-130.2 |
| Ukubonakala kwesisombululo | Ayinombala ogqamile kunesixazululo sokubhekisela se-BY7 | Imithetho |
| PH | 6.0~7.5 | 6.86 |
| Izinto ezihlanganisiwe | Hlola njengoba kuboniswe ku-EP10.0 | Imithetho |
| Izinto ezikwazi ukukhiqizwa kalula nge-carbon | Isixazululo sesampula asinawo umbala ongaphezu koketshezi oluhambisanayoA | Imithetho |
| Ukulahlekelwa ekuwomeni (%) | 20.5 | 0.03 |
| Umlotha oxutshwe ne-sulfate(%) | 20.1 | 0.0 |
| Izinsalela ekushiseni (%) | ≤0.1 | 0.0 |
| Izinsimbi ezisindayo (mglkg) | ≤20 | -20 |
| ISIPHETHO | OKUFANELEKILE (Ukuthobela nge I-USP2022 futhi I-EP10.0stfuthi) | |
Ukusetshenziswa
- Ukufumisa, ukulawula uwoyela, kanye nokunciphisa ama-blackheads: I-Niacinamide inganciphisa ngempumelelo ukulahleka kwamanzi e-transepidermal. Nakuba umphumela wayo uma isetshenziswa yodwa ungemuhle njengowe-hyaluronic acid kanye ne-glycerin, umphumela uma isetshenziswa ngokuhlangene ngokuqinisekile u-1+1>2; i-niacinamide ingathulisa izindlala ze-sebaceous "ezisebenza ngokweqile", ngaleyo ndlela ifinyelele ukulawula uwoyela futhi inciphise ama-blackheads kanye nama-acne.
- Amandla amahle okulwa nemibimbi: Amandla okulwa nemibimbi e-niacinamide atholakala emandleni ayo okusebenzisa i-ATP, anikeze amandla kuma-keratinocyte, andise ukwakheka kwe-collagen, futhi inekhono elihle lokusebenzisana, elingasetshenziswa kanye nezinye izithako zokulwa nemibimbi.
- Umphumela omuhle wokuvikela ilanga osizayo: Umonakalo obangelwa imisebe ye-ultraviolet emzimbeni womuntu awugcini nje ngokushiswa kwesikhumba, kodwa futhi nokucindezelwa kwamasosha omzimba (i-Chemicalbook) ngisho nomdlavuza wesikhumba. Izifundo eziningi ekhaya nakwamanye amazwe zikhombisile ukuthi i-niacinamide inganciphisa ngempumelelo ukuvela kwe-photoimmunosuppression yesikhumba ngesikhathi sokukhanya kwe-ultraviolet.
- Ubumnene obuhle: Uma kuqhathaniswa nezithako ezifana ne-vitamin C kanye ne-resorcinol derivatives, i-niacinamide imnene kakhulu futhi ingasetshenziswa ngabantu abanezinhlobo eziningi zesikhumba. Kodwa-ke, kufanele kuqashelwe ukubekezelelana kwesikhumba. Isibonelo, i-Ordinary Whitening Essence ene-10% niacinamide concentration isenokucasuka okuthile. Ngakho-ke, kungcono ukwenza isivivinyo sokubekezelelana kwesikhumba ngaphambi kokusebenzisa. Yisebenzise kuphela ngemva kokuqinisekisa ukubekezelelana, futhi ngesikhathi esifanayo, qaphela ukuthi ungayisebenzisi nemikhiqizo equkethe i-asidi efana ne-salicylic acid kanye ne-fruit acid ukuvimbela ukucasuka ngokweqile esikhumbeni.
I-amide derivative ye-vitamin B3 kanye ne-PARP inhibitor
Imithi yamavithamini ibamba iqhaza ezinqubweni ze-metabolic emzimbeni futhi isetshenziselwa ukuvimbela nokwelapha i-pellagra nezinye izifo zokuntuleka kwe-niacin.
I-Niacinamide inokuncibilika kwamanzi okungcono kune-niacin, kodwa yakha kalula ama-complex ane-vitamin C nama-clumps. Umthamo u-30-80mg/kg. Uma isetshenziswa emikhiqizweni yokunakekelwa kwesikhumba, ingavimbela isikhumba esiqinile, igcine impilo yamaseli esikhumba, futhi ikhuthaze ukumhlophe kwesikhumba. Uma isetshenziswa ekunakekelweni kwezinwele, ingakhuthaza ukujikeleza kwegazi ekhanda, igcine ama-follicle ezinwele ephilile, ikhuthaze ukukhula kwezinwele, futhi ivimbele ukulahleka kwezinwele.
Ukupakisha Nokuthumela
25KG/Isigubhu noma ngokwezidingo zamakhasimende.
Kungokwempahla evamile futhi kungathunyelwa ngolwandle nangomoya
Gcina futhi ugcine
Isikhathi sokuphila: Izinyanga ezingama-24 kusukela ngosuku lokwenziwa kwento epakishweni lokuqala elingavulwanga, igcinwe endaweni epholile neyomile kude nokukhanya kwelanga okuqondile, amanzi.
Indawo yokugcina izinto enomoya, Ukomisa okuphansi kwezinga lokushisa, Ihlukaniswe nama-oxidants, ama-acid.
