I-Ursodeoxycholic acid/UDCA/CAS: 128-13-2
Incazelo emfushane:
Igama Lomkhiqizo: i-Ursodeoxycholic acid
I-CAS: 128-13-2
Uhlobo: ZA-Y
MF:C24H40O4
I-MW:392.57
ISAKHIWO:
Incazelo:
I-Ursodeoxycholic acid (UDCA) iyi-bile acid yesibili esiza ukulawula i-cholesterol. Ukuhlaziywa kwe-UDCA okusekelwe ku-mass spectrometry kwenziwa njalo ezicelweni zokuhlola ukuxilongwa kwemitholampilo njengokuhlolwa kwezinsana kwamaphutha okuzalwa kokwenziwa kwe-bile acid, ukuhlukanisa phakathi kwezinhlobo ze-cholestasis yomndeni ye-intrahepatic, kanye nokuqapha ukwelashwa kwezimpendulo zesiguli ekwelashweni kwe-UDCA. Lesi Sixazululo Esiqinisekisiwe Se-Spiking sifanelekile njengezinto zokuqala ekulungiseleleni amazinga okulingana, ama-calibrator, kanye nezilawuli zokusetshenziswa ezindleleni zokuhlola i-bile acid ye-LC-MS/MS kanye ne-GC/MS.
Imininingwane:
| Into | Imininingwane |
| Indawo yokuncibilika | 203-204 °C (ngokukhanya) |
| Indawo yokubilisa | 437.26°C (isilinganiso esilinganiselwe) |
| Ubuningi | 0.9985 (isilinganiso esilinganiselwe) |
| Fp | 9℃ |
| Inkomba yokubuka | 60.5 ° (C=2, EtOH) |
| Izinga lokushisa lesitoreji. | 2-8°C |
| Ukuncibilika | i-ethanol: 50 mg/mL, icacile |
| Ifomu | Okuqinile. Impuphu. |
| Umbala | Okumhlophe - cishe okumhlophe. |
Ukusetshenziswa
I-Ursodeoxycholic acid iyi-bile salt eyenzeka ngokwemvelo kubantu. Imuncwa ngokushesha emathunjini amancane bese ikhishwa ne-bile. I-Ursodeoxycholic acid iyisidakamizwa se-choise sokwelapha i-primary biliary cirrhosis kanye ne-primary sclerosis cholanyitis. Umthamo wansuku zonke ufinyelela ku-10-15 mg/kg. Ayinazo imiphumela emibi ngisho nangemva kwesikhathi sokwelashwa esifinyelela eminyakeni engama-20.
Ukuqedwa kwamatshe enyongo. Isetshenziswa kakhulu ekwelapheni amatshe enyongo e-cholesterol angasebenzi, izoba nesivinini sokwelapha ikakhulukazi uma inyongo ijwayelekile, amatshe anobubanzi obungu-15mm noma ngaphansi, amatshe e-cholesterol angena nge-X-ray, angakagayiwe futhi antantayo kakhulu.
I-Ursodeoxycholic acid ingathuthukisa nokusebenza kahle kwe-α-interferon ekwelapheni i-hepatitis C engapheli. Ingasetshenziswa futhi ekwelapheni isifo sohudo, ukuqunjelwa okungavamile, ukusabela kokungezwani komzimba, ukulunywa, ikhanda elibuhlungu, isiyezi, ubuhlungu besisu, i-pancreatitis kanye ne-bradycardia Iziguli ezivalekile ngokuphelele noma ukungasebenzi kahle kwesibindi okukhulu kanye nabesifazane abakhulelwe kufanele bagweme ukusebenzisa.
I-Ursodeoxycholic acid (UDCA) iyisivikelo samaseli esisetshenziswa kakhulu ukunciphisa izifo zesibindi kanye nezenyongo. I-Ursodeoxycholic acid ingasetshenziswa ukutadisha imisebenzi yayo ethile esukela ekunciphiseni ukumuncwa kwe-cholesterol, ukuncibilikiswa kwe-cholesterol gallstone kuya ekucindezelweni kwempendulo yomzimba. Iphinde isetshenziswe njenge-anticholelithogenic. I-Epimer ene-Chenodiol maqondana neqembu le-hydroxyl ku-C7.
Ukupakisha Nokuthumela
25KG/Isigubhu.
Kungokwempahla evamile futhi kungathunyelwa ngolwandle nangomoya
Gcina futhi ugcine
Isikhathi sokuphila: Izinyanga ezingama-24 kusukela ngosuku lokwenziwa kwento epakishweni lokuqala elingavulwanga, igcinwe endaweni epholile neyomile kude nokukhanya kwelanga okuqondile, amanzi.
Indawo yokugcina izinto enomoya, Ukomisa okuphansi kwezinga lokushisa, Ihlukaniswe nama-oxidants, ama-acid.
