Ursodeoxycholic acid/UDCA/CAS: 128-13-2
Nkọwa Dị Mkpirikpi:
Aha Ngwaahịa: Ursodeoxycholic acid
CAS: 128-13-2
Ụdị: ZA-Y
MF:C24H40O4
MW:392.57
ỤDỊ:
Nkọwa:
Ursodeoxycholic acid (UDCA) bụ acid bile nke abụọ nke na-enyere aka ịchịkwa cholesterol. A na-eme nyocha UDCA dabere na oke spectrometry na ngwa nyocha ahụike dịka nnwale ụmụ amụrụ ọhụrụ nke mmejọ n'ime ọmụmụ nke njikọta bile acid, iche iche n'etiti ụdị cholestasis intrahepatic ezinụlọ, na nlekota ọgwụgwọ nke nzaghachi ndị ọrịa na ọgwụgwọ UDCA. Ngwọta Spiking a akwadoro dabara adaba dị ka ihe mmalite maka nkwadebe nke ọkọlọtọ linearity, calibrators, na njikwa maka ojiji na usoro nnwale bile acid LC-MS/MS na GC/MS.
Nkọwapụta:
| ihe | Nkọwapụta |
| Ebe agbaze | 203-204 Celsius (ọkụ) |
| Ebe isi mmiri | 437.26°C (atụmatụ dị oke njọ) |
| Njupụta | 0.9985 (atụmatụ dị oke ọnụ ahịa) |
| Fp | 9℃ |
| Ndekọ Refractive | 60.5 Celsius (C=2, EtOH) |
| Okpomọkụ nchekwa. | 2-8°C |
| Mmiri na-agbaze | ethanol: 50 mg/mL, doro anya |
| Ụdị | Ntụ ntụ siri ike. |
| Agba | Ọcha - ihe fọrọ nke nta ka ọ bụrụ ọcha. |
Ojiji
Ursodeoxycholic acid bụ nnu bile nke na-apụta n'ime mmadụ. A na-etinye ya ngwa ngwa n'ime obere eriri afọ ma na-apụ ya na bile. Ursodeoxycholic acid bụ ọgwụ a na-eji eme ihe maka ọgwụgwọ nke ọrịa biliary cirrhosis na ọrịa sclerosis nke mbụ. Ọgwụ a na-enye kwa ụbọchị bụ 10-15 mg/kg. Ọ naghị enwe mmetụta ọ bụla ọbụlagodi mgbe oge ọgwụgwọ ruru afọ 20 gasịrị.
Ngbaze nke nkume gallstone. A na-ejikarị ya agwọ ọrịa gallstone cholesterol a na-apụghị ịgwọ, ọ ga-agwọkwa nke ọma, ọkachasị ma ọ bụrụ na gallbladder bụ ihe nkịtị, nkume nwere dayameta 15mm ma ọ bụ obere, X-ray na-abanye n'ime, nkume cholesterol na-adịghị agbaze na nke na-ese n'elu mmiri.
Ursodeoxycholic acid nwekwara ike ime ka α-interferon dịkwuo mma n'ọgwụgwọ ọrịa hepatitis C na-adịghị ala ala. A pụkwara iji ya gwọọ afọ ọsịsa, afọ ntachi na-adịghị ahụkebe, mmeghachi omume nfụkasị ahụ, itching, isi ọwụwa, isi ọwụwa, mgbu afọ, pancreatitis na bradycardia. Ndị ọrịa nwere nsogbu biliary kpamkpam ma ọ bụ nsogbu imeju siri ike na ụmụ nwanyị dị ime kwesịrị izere iji ya.
Ursodeoxycholic acid (UDCA) bụ ihe na-echebe mkpụrụ ndụ nke a na-eji eme ihe nke ukwuu iji belata ọrịa imeju na biliary. Enwere ike iji Ursodeoxycholic acid mụọ ọrụ ya kpọmkwem, site na mbelata nnabata cholesterol, mgbasa nke cholesterol gallstone ruo na igbochi nzaghachi ahụ ji alụso ọrịa ọgụ. A na-ejikwa ya dị ka ihe na-egbochi mmeghachi omume ahụ ji alụso ọrịa ọgụ. Epimer na Chenodiol n'ihe gbasara otu hydroxyl na C7.
Nkwakọ ngwaahịa na Mbupu
25KG/Drum.
Ọ bụ nke ngwongwo nkịtị ma nwee ike ibuga ya site n'oké osimiri na ikuku
Debe ma chekwaa
Ndụ nchekwa: ọnwa 24 site na ụbọchị emepụtara ya na ngwugwu mbụ e meghebeghị emepe echekwara n'ebe dị jụụ na kpọrọ nkụ nke na-anaghị anwụ kpọmkwem, mmiri.
Ụlọ nkwakọba ihe ikuku, Ọkụ dị ala, Nkewapụrụ na ihe ndị na-eme ka oxidants, asịd.
