I-Ursodeoxycholic acid/UDCA/CAS: 128-13-2
Inkcazo emfutshane:
Igama leMveliso: i-Ursodeoxycholic acid
I-CAS: 128-13-2
Uhlobo: ZA-Y
MF:C24H40O4
MW:392.57
ULWAKHIWO:
Inkcazo:
I-Ursodeoxycholic acid (UDCA) yi-bile acid yesibini enceda ekulawuleni i-cholesterol. Uhlalutyo olusekelwe kwi-mass spectrometry lwe-UDCA lwenziwa rhoqo kwizicelo zovavanyo lweklinikhi ezifana novavanyo lweentsana ezisandula ukuzalwa lweempazamo zokwenziwa kwe-bile acid, ukwahlula phakathi kweentlobo ze-cholestasis ye-intrahepatic yosapho, kunye nokubeka esweni iimpendulo zesigulana kunyango lwe-UDCA. Esi Sisombululo seSpiking esiQinisekisiweyo sifanelekile njengesixhobo sokuqala ekulungiseleleni imigangatho yomgca, ii-calibrators, kunye nolawulo lokusetyenziswa kwiindlela zovavanyo lwe-bile acid ye-LC-MS/MS kunye ne-GC/MS.
Inkcazo:
| Into | Inkcazo |
| Indawo yokunyibilika | 203-204 °C (elikhanyayo) |
| Indawo yokubila | 437.26°C (uqikelelo oluqikelelweyo) |
| Uxinano | 0.9985 (uqikelelo oluqikelelweyo) |
| Fp | 9℃ |
| Isalathisi sokubonisa ukukhanya | 60.5 ° (C=2, EtOH) |
| Ubushushu bokugcina. | 2-8°C |
| Ukunyibilika | i-ethanol: 50 mg/mL, icacile |
| Ifomu | Iqinile. Umgubo. |
| Umbala | Mhlophe - phantse mhlophe. |
Ukusetyenziswa
I-Ursodeoxycholic acid yityuwa ye-bile eyenzeka ngokwemvelo ebantwini. Ifunxwa ngokukhawuleza emathunjini amancinci kwaye ikhutshwe kunye ne-bile. I-Ursodeoxycholic acid sisiyobisi se-choise sokunyanga i-primary biliary cirrhosis kunye ne-primary sclerosis cholanyitis. Idosi yemihla ngemihla ifikelela kwi-10-15 mg/kg. Ayinazo iziphumo ebezingalindelekanga nangona ixesha lonyango elifikelela kwiminyaka engama-20.
Ukunyibilika kwamatye enyongo. Isetyenziswa kakhulu kunyango lwamatye enyongo e-cholesterol angasebenziyo, iya kuba nesantya sokuphiliswa ngakumbi kwimeko apho inyongo iqhelekile, amatye anobubanzi obuyi-15mm okanye ngaphantsi, amatye e-X-ray angena kwi-enertable, angena-calcified kwaye amatye e-cholesterol ahambahambayo.
I-Ursodeoxycholic acid inokuphucula ukusebenza kwe-α-interferon kunyango lwe-hepatitis C engapheliyo. Ingasetyenziselwa ukunyanga urhudo, ukuqhina okungaqhelekanga, ii-allergy reactions, ukurhawuzelela, intloko ebuhlungu, isiyezi, iintlungu zesisu, i-pancreatitis kunye ne-bradycardia. Izigulane ezivaleke ngokupheleleyo okanye ezingasebenzi kakuhle kwesibindi kunye nabasetyhini abakhulelweyo kufuneka baphephe ukusebenzisa.
I-Ursodeoxycholic acid (UDCA) sisithinteli seeseli esisetyenziswa kakhulu ukunciphisa izifo zesibindi kunye nenyongo. I-Ursodeoxycholic acid ingasetyenziselwa ukufunda imisebenzi yayo ethile eqala ekunciphiseni ukufunxwa kwe-cholesterol, ukuchithwa kwe-cholesterol gallstone ukuya ekuthinteleni impendulo yomzimba. Ikwasetyenziswa njenge-anticholelithogenic. I-Epimer eneChenodiol ngokubhekiselele kwiqela le-hydroxyl kwi-C7.
Ukupakishwa kunye nokuthunyelwa
25KG/Idrama.
Yeyokwempahla eqhelekileyo kwaye inokuhanjiswa ngolwandle nangomoya
Gcina kwaye ugcine
Ixesha lokuphelelwa: Iinyanga ezingama-24 ukususela kumhla wokwenziwa kwayo kwiphakheji yokuqala engavulwanga igcinwe kwindawo epholileyo neyomileyo kude nelanga elithe ngqo, amanzi.
Indawo yokugcina umoya, Ukomisa kubushushu obuphantsi, Yahlulwe kwii-oxidants, ii-asidi.
