Asidi ya Ursodeoxycholic/UDCA/CAS: 128-13-2
Kufotokozera Kwachidule:
Dzina la Mankhwala: Ursodeoxycholic acid
CAS: 128-13-2
Mtundu: ZA-Y
MF:C24H40O4
MW:392.57
KAYAMBIDWE:
Kufotokozera:
Ursodeoxycholic acid (UDCA) ndi asidi yachiwiri ya bile yomwe imathandiza kuwongolera cholesterol. Kusanthula kwa UDCA kochokera ku mass spectrometry kumachitika nthawi zonse poyesa matenda monga kuyesa kwa makanda obadwa kumene za zolakwika zobadwa nazo za kapangidwe ka bile acid, kusiyanitsa mitundu ya cholestasis ya m'chiwindi cha m'banja, komanso kuyang'anira momwe odwala amayankhira ku chithandizo cha UDCA. Njira Yotsimikizika ya Spiking iyi ndi yoyenera ngati chinthu choyambira pokonzekera miyezo yolunjika, zowerengera, ndi zowongolera zogwiritsidwa ntchito mu njira zoyesera bile acid ya LC-MS/MS ndi GC/MS.
Mafotokozedwe:
| Chinthu | Kufotokozera |
| Malo osungunuka | 203-204 °C (lit.) |
| Malo otentha | 437.26°C (kuyerekezera koyenera) |
| Kuchulukana | 0.9985 (chiyerekezo choyerekeza) |
| Fp | 9℃ |
| Chizindikiro cha refractive | 60.5 ° (C=2, EtOH) |
| Kutentha kwa malo osungira. | 2-8°C |
| Kusungunuka | ethanol: 50 mg/mL, yoyera |
| Fomu | Ufa wolimba. |
| Mtundu | Choyera - pafupifupi choyera. |
Kagwiritsidwe Ntchito
Ursodeoxycholic acid ndi mchere wa ndulu womwe umapezeka mwachibadwa mwa anthu. Umalowa mwachangu m'matumbo ang'onoang'ono ndipo umatuluka ndi ndulu. Ursodeoxycholic acid ndi mankhwala a choise ochizira matenda oyamba a biliary cirrhosis ndi primary sclerosis cholanyitis. Mlingo wa tsiku ndi tsiku ndi 10-15 mg/kg. Ulibe zotsatirapo zoyipa ngakhale patatha zaka 20 chithandizo.
Kusungunuka kwa miyala ya ndulu. Imagwiritsidwa ntchito makamaka pochiza miyala ya ndulu ya cholesterol yosagwira ntchito, imakhala ndi mphamvu yochira makamaka ngati nduluyo ili yabwinobwino, miyala ili ndi mainchesi 15mm kapena kutsika, X-ray yolowera, yosasungunuka komanso miyala ya cholesterol yoyandama kwambiri.
Ursodeoxycholic acid ingathandizenso kuchiza matenda a chiwindi a C osatha. Ingagwiritsidwenso ntchito pochiza kutsegula m'mimba, kudzimbidwa kosazolowereka, ziwengo, kuyabwa, mutu, chizungulire, kupweteka m'mimba, kapamba ndi bradycardia Odwala omwe ali ndi vuto la ndulu yotsekeka kapena chiwindi chawo sichikugwira ntchito bwino komanso amayi apakati ayenera kupewa kugwiritsa ntchito mankhwalawa.
Ursodeoxycholic acid (UDCA) ndi mankhwala oteteza maselo omwe amagwiritsidwa ntchito kwambiri pochepetsa matenda a chiwindi ndi ndulu. Ursodeoxycholic acid ingagwiritsidwe ntchito pophunzira ntchito zake zapadera kuyambira kuchepetsa kuyamwa kwa cholesterol, kusungunuka kwa cholesterol m'mitsempha ya ndulu mpaka kuletsa chitetezo chamthupi. Imagwiritsidwanso ntchito ngati anticholelithogenic. Epimer yokhala ndi Chenodiol poyerekeza ndi gulu la hydroxyl pa C7.
Kulongedza ndi Kutumiza
25KG/Ngoma.
Ndi katundu wamba ndipo amatha kutumizidwa kudzera m'nyanja ndi mlengalenga
Sungani ndi kusunga
Nthawi yosungiramo zinthu: Miyezi 24 kuyambira tsiku lopangidwa m'maphukusi oyambirira osatsegulidwa, osungidwa pamalo ozizira komanso ouma, kutali ndi dzuwa, madzi.
Nyumba yosungiramo zinthu zopumira mpweya, Youma pang'ono, Yosiyana ndi ma oxidants, ma acid.
