INicotinamide/CAS:98-92-0
Inkcazo emfutshane:
Igama lemveliso: iNicotinamide
Uhlobo:ZA-N
I-CAS:98-92-0
MF:C6H6N2O
I-MW: 122.12
ULWAKHIWO:
Ubuninzi: 1.40
iqondo lokunyibilika: 182 °C
I-Niacinamide yikristale emhlophe efana nenaliti okanye umgubo wekristale, ayinavumba okanye inevumba elincinci, inencasa ekrakra kancinci. Ubuninzi bayo yi-1.4, kwaye indawo yayo yokunyibilika yi-129-131℃. I-1g yale mveliso inokunyibilika kwi-1mL yamanzi, i-1.5mL ye-ethanol, okanye i-10mL ye-glycerol, kodwa hayi kwi-ether. I-pH yesisombululo samanzi se-10% yi-6.5-7.5. Ine-hygroscopicity ebuthathaka. Izinzile, imelana nee-asidi, ii-alkalis, kunye namaqondo obushushu aphezulu. Izinzile ekukhanyeni nasekufudumaleni emoyeni owomileyo, kodwa xa ifudunyezwa kwizisombululo ze-alkaline okanye ze-asidi, yenza i-nicotinic acid. I-LD50 yomlomo kwiimpuku yi-2.5-3.5g/kg, kwaye ixabiso le-ADI alichazwanga ngokuthe ngqo (ECC, 1990).
iinkcukacha
| IZINTO | IINKCUKACHA | UVAVANYO IZIPHUMO |
| Inkangeleko | Umgubo omhlophe wekristale | Ithobela imithetho |
| Ukunyibilika | Inyibilika simahla emanzini nakwi-ethanol engenamanzi, inyibilika kancinci kwi-methylene chloride | Ithobela imithetho |
|
Ukuchongwa | A: Ukufunxwa kwe-infrared | Ithobela imithetho |
| B: Ukufunxwa kwe-Ultraviolet. Umlinganiselo we-A245/A262 yi-0.63-0.67 | 0.66 | |
| C. I-chromatogrzphy enomaleko omncinci | Ithobela imithetho | |
| Uvavanyo(%) | 99.0~101.0 | 100.1 |
| Uluhlu lokunyibilika (□) | 128~131 | 128.7-130.2 |
| Inkangeleko yesisombululo | Ayinambala ubukhali ngaphezu kwesisombululo sereferensi se-BY7 | Ithobela imithetho |
| PH | 6.0~7.5 | 6.86 |
| Izinto ezixutyiweyo | Vavanya ngokwe-EP10.0 | Ithobela imithetho |
| Izinto ezikwaziyo ukunyibilika ngokukhawuleza | Isisombululo sesampulu asinambala ungaphezulu kolwelo oluhambelanayo | Ithobela imithetho |
| Ilahleko xa yomiswa (%) | 20.5 | 0.03 |
| Uthuthu olune-sulfate(%) | 20.1 | 0.0 |
| Intsalela ekutshiseni (%) | ≤0.1 | 0.0 |
| Iintsimbi ezinzima (mglkg) | ≤20 | -20 |
| ISIPHELO | IFANELEKILEYO (Thobela kunye I-USP2022 kwaye I-EP10.0stkwaye) | |
Ukusetyenziswa
- Ukufumisa, ukulawula ioyile, kunye nokunciphisa amabala amnyama: I-Niacinamide inokunciphisa ngempumelelo ukulahleka kwamanzi e-transepidermal. Nangona isiphumo sayo xa isetyenziswa yodwa singesihle njenge-hyaluronic acid kunye ne-glycerin, isiphumo xa sisetyenziswa ngokudibeneyo ngokuqinisekileyo singu-1+1>2; i-niacinamide inokuzolisa amadlala e-sebaceous "asebenza kakhulu", ngaloo ndlela ifezekisa ulawulo lweoyile kwaye inciphise amabala amnyama kunye ne-acne.
- Amandla okulwa nemibimbi: Amandla okulwa nemibimbi e-niacinamide axhomekeke kumandla ayo okusebenzisa i-ATP, ukunika amandla kwiikeratinocytes, ukwandisa ukwenziwa kwe-collagen, kwaye inamandla amahle okusebenzisana, anokusetyenziswa kunye nezinye izithako zokulwa nemibimbi.
- Isiphumo esihle sokukhusela ilanga: Umonakalo obangelwa yimitha ye-ultraviolet emzimbeni womntu awupheleli nje ekutshiseni ilanga, kodwa ukwathintela amasosha omzimba (iChemicalbook) kwanomhlaza wolusu. Izifundo ezininzi ekhaya nakwamanye amazwe zibonise ukuba i-niacinamide inokunciphisa ngempumelelo ukuvela kwe-photoimmunosuppression yolusu ngexesha lokukhanyiswa kwemitha ye-ultraviolet.
- Ubulali obuhle: Xa kuthelekiswa nezithako ezifana ne-vitamin C kunye ne-resorcinol derivatives, i-niacinamide ithambile kwaye ingasetyenziswa ngabantu abaneentlobo ezahlukeneyo zolusu. Nangona kunjalo, kufuneka kuqwalaselwe ukunyamezela ulusu. Umzekelo, i-Ordinary Whitening Essence ene-10% niacinamide concentration isenolusu oluthile olurhawuzelelwayo. Ke ngoko, kungcono ukwenza uvavanyo lokunyamezela ulusu ngaphambi kokusetyenziswa. Yisebenzise kuphela emva kokuqinisekisa ukunyamezela, kwaye kwangaxeshanye, lumka ungayisebenzisi kunye neemveliso ezine-asidi ezifana ne-salicylic acid kunye ne-fruit acid ukuthintela ukurhawuzelelwa okugqithisileyo eluswini.
I-amide derivative ye-vitamin B3 kunye ne-PARP inhibitor
Amayeza eevithamini athatha inxaxheba kwiinkqubo zemetabolism emzimbeni kwaye asetyenziselwa ukuthintela nokunyanga i-pellagra kunye nezinye izifo zokungabikho kwe-niacin.
I-Niacinamide inokunyibilika kwamanzi okungcono kune-niacin, kodwa yenza lula ii-complexes ezine-vitamin C kunye nama-clumps. Umthamo yi-30-80mg/kg. Xa isetyenziswa kwiimveliso zokhathalelo lolusu, inokuthintela ulusu olurhabaxa, igcine impilo yeeseli zolusu, kwaye ikhuthaze ukumhlophe kolusu. Xa isetyenziswa ekukhathaleleni iinwele, inokukhuthaza ukujikeleza kwegazi entlokweni, igcine iifollicle zeenwele ziphilile, ikhuthaze ukukhula kweenwele, kwaye ithintele ukulahleka kweenwele.
Ukupakishwa kunye nokuthunyelwa
25KG/Idrama okanye ngokweemfuno zomthengi.
Yeyokwempahla eqhelekileyo kwaye inokuhanjiswa ngolwandle nangomoya
Gcina kwaye ugcine
Ixesha lokuphelelwa: Iinyanga ezingama-24 ukususela kumhla wokwenziwa kwayo kwiphakheji yokuqala engavulwanga igcinwe kwindawo epholileyo neyomileyo kude nelanga elithe ngqo, amanzi.
Indawo yokugcina umoya, Ukomisa kubushushu obuphantsi, Yahlulwe kwii-oxidants, ii-asidi.
