Nicotinamide/CAS: 98-92-0
Kev Piav Qhia Luv:
Lub npe khoom: Nicotinamide
Hom: ZA-N
CAS: 98-92-0
MF:C6H6N2O
MW: 122.12
QAUV:
Qhov Ceev: 1.40
Lub ntsiab lus yaj: 182 ° C
Niacinamide yog ib qho siv lead ua dawb zoo li koob lossis hmoov crystalline, tsis muaj ntxhiab lossis me ntsis tsw, nrog rau qhov saj iab me ntsis. Nws qhov ceev yog 1.4, thiab nws lub ntsiab lus yaj yog 129-131 ℃. 1g ntawm cov khoom no tuaj yeem yaj rau hauv 1mL dej, 1.5mL ntawm ethanol, lossis 10mL ntawm glycerol, tab sis tsis yog hauv ether. Lub pH ntawm 10% aqueous kua yog 6.5-7.5. Nws muaj hygroscopicity tsis muaj zog. Nws ruaj khov, tiv taus cov kua qaub, alkalis, thiab kub siab. Nws ruaj khov rau lub teeb thiab cua sov hauv huab cua qhuav, tab sis thaum cua sov hauv alkaline lossis acidic kua, nws tsim cov kua qaub nicotinic. LD50 hauv qhov ncauj hauv nas yog 2.5-3.5g / kg, thiab tus nqi ADI tsis tau teev tseg tshwj xeeb (ECC, 1990).
cov lus qhia tshwj xeeb
| COV KHOOM | COV LUS QHIA | KEV NTSUAM XYUAS TXAUS SIAB |
| Qhov tsos | Dawb crystalline hmoov | Ua raws li |
| Kev yaj tau | Dawb soluble hauv dej thiab hauv anhydrous ethanol, me ntsis soluble hauv methylene chloride | Ua raws li |
|
Kev txheeb xyuas tus kheej | A: Kev nqus infrared | Ua raws li |
| B: Kev nqus dej ultraviolet. Qhov piv ntawm A245 / A262 yog 0.63-0.67 | 0.66 | |
| C. Cov chromatograph nyias-txheej | Ua raws li | |
| Kev Ntsuas (%) | 99.0~101.0 | 100.1 |
| Qhov ntau ntawm kev yaj (□) | 128~131 | 128.7-130.2 |
| Cov tsos ntawm cov tshuaj | Tsis muaj xim ntau dua li cov tshuaj siv los ntawm BY7 | Ua raws li |
| PH | 6.0~7.5 | 6.86 |
| Cov tshuaj uas tau muab tso rau hauv | Sim raws li EP10.0 | Ua raws li |
| Cov khoom uas yooj yim carbonized | Cov kua qauv tsis muaj xim ntau dua li cov kua sib phim A | Ua raws li |
| Poob ntawm qhov ziab (%) | 20.5 | 0.03 |
| Cov tshauv sulfated (%) | 20.1 | 0.0 |
| Cov seem ntawm igmition (%) | ≤0.1 | 0.0 |
| Cov hlau hnyav (mg / kg) | ≤20 | -20 |
| XAUS LUS | TXAUS SIAB (Ua raws li nrog USP2022 thiab EP10.0sttus qauv) | |
Kev Siv
- Ua kom noo noo, tswj roj, thiab txo cov pob dub: Niacinamide tuaj yeem txo cov dej ntws los ntawm daim tawv nqaij. Txawm hais tias nws cov nyhuv thaum siv ib leeg tsis zoo li hyaluronic acid thiab glycerin, qhov cuam tshuam thaum siv ua ke yog 1 + 1> 2; niacinamide tuaj yeem ua rau cov qog sebaceous "ua haujlwm ntau dhau", yog li ua tiav kev tswj roj thiab txo cov pob dub thiab pob txuv.
- Muaj peev xwm tiv thaiv kev laus zoo: Lub peev xwm tiv thaiv kev laus ntawm niacinamide nyob rau hauv nws lub peev xwm los ua kom ATP ua haujlwm, muab lub zog rau keratinocytes, nce collagen synthesis, thiab nws muaj peev xwm ua haujlwm zoo, uas tuaj yeem siv ua ke nrog lwm cov khoom xyaw tiv thaiv kev laus.
- Kev tiv thaiv hnub zoo: Kev puas tsuaj los ntawm cov teeb ultraviolet rau tib neeg lub cev tsis yog tsuas yog tanning, tab sis kuj tseem tiv thaiv kab mob (Chemicalbook) thiab txawm tias mob qog nqaij hlav. Ntau txoj kev tshawb fawb hauv tsev thiab txawv teb chaws tau qhia tias niacinamide tuaj yeem txo qhov tshwm sim ntawm daim tawv nqaij photoimmunosuppression thaum lub sijhawm ultraviolet irradiation.
- Kev mos mos zoo: Piv nrog cov khoom xyaw xws li vitamin C thiab resorcinol derivatives, niacinamide yog qhov mos mos heev thiab tuaj yeem siv los ntawm cov neeg uas muaj ntau hom tawv nqaij. Txawm li cas los xij, tseem yuav tsum tau them sai sai rau kev kam rau tawv nqaij. Piv txwv li, The Ordinary Whitening Essence nrog 10% niacinamide concentration tseem muaj qee qhov khaus. Yog li ntawd, nws yog qhov zoo tshaj plaws los ua qhov kev sim kam rau tawv nqaij ua ntej siv. Tsuas yog siv nws tom qab lees paub qhov kam rau, thiab tib lub sijhawm, ceev faj tsis txhob siv nws nrog cov khoom muaj kua qaub xws li salicylic acid thiab txiv hmab txiv ntoo acid kom tiv thaiv kev khaus ntau dhau rau tawv nqaij.
Ib qho amide derivative ntawm vitamin B3 thiab PARP inhibitor
Cov tshuaj vitamin koom nrog cov txheej txheem metabolic hauv lub cev thiab siv los tiv thaiv thiab kho pellagra thiab lwm yam kab mob niacin deficiency.
Niacinamide yaj tau zoo dua hauv dej dua li niacin, tab sis nws yooj yim tsim cov khoom sib xyaw nrog vitamin C thiab cov pawg. Qhov ntau npaum li cas yog 30-80mg / kg. Thaum siv rau hauv cov khoom siv saib xyuas tawv nqaij, nws tuaj yeem tiv thaiv cov tawv nqaij ntxhib, tswj kev noj qab haus huv ntawm cov hlwb tawv nqaij, thiab txhawb kom tawv nqaij dawb. Thaum siv rau hauv kev saib xyuas plaub hau, nws tuaj yeem txhawb kev ncig ntshav hauv lub taub hau, ua kom cov plaub hau noj qab haus huv, txhawb kom cov plaub hau loj hlob, thiab tiv thaiv kom plaub hau poob.
Ntim thiab Xa Khoom
25KG / Nruas los yog raws li cov neeg siv khoom xav tau.
Yog cov khoom siv dav dav thiab tuaj yeem xa los ntawm dej hiav txwv thiab huab cua
Khaws cia thiab khaws cia
Lub neej txee: 24 lub hlis txij li hnub tsim khoom hauv cov ntim khoom tsis tau qhib khaws cia rau hauv qhov chaw txias thiab qhuav kom tsis txhob raug tshav ntuj ncaj qha, dej.
Lub tsev rau khoom muaj cua nkag, ziab kom qhuav kub tsawg, Sib cais ntawm cov tshuaj oxidants, cov kua qaub.
