Ngomhlaka-11 Disemba 2024, inkampani ehamba phambili ye-biotechnology yasekhaya yamemezela ukuthi ifinyelele intuthuko enkulu ocwaningweni nasekuthuthukisweni kwe-recombinant human serum albumin (rHSA). Lokhu kufeza kuphawula isinyathelo esibalulekile eShayina emkhakheni we-biomedicine futhi kunomthelela omkhulu embonini yezempilo yomhlaba wonke.
I-albumin ye-serum yomuntu ephinde yahlanganiswa uhlobo lwe-albumin ye-serum yomuntu ekhiqizwa ngobuchwepheshe bobunjiniyela bezakhi zofuzo. I-albumin ye-serum ingenye yezingxenye eziyinhloko zeprotheyini ku-plasma yomuntu, ebalelwa cishe ku-50% kuya ku-60% weprotheyini iyonke ye-plasma. Idlala indima ebalulekile ekugcineni ingcindezi ye-plasma colloid osmotic kanye nokuthutha izinto ezahlukahlukene (njengama-hormone, amavithamini, amaminerali, kanye nemithi). Ngaphezu kwalokho, i-albumin inemisebenzi eminingi yomzimba, okuhlanganisa ukuhlinzeka ngokudla okunempilo, ukuhlanza umzimba, kanye nokulawula imisebenzi yokuzivikela komzimba.
Sekuyisikhathi eside, i-albumin ye-serum yomuntu ikhishwe kakhulu ku-plasma yomuntu. Kodwa-ke, le ndlela inemikhawulo eminingi, njengemithombo elinganiselwe yezinto zokusetshenziswa, ingozi engaba khona yokungcoliswa yigciwane, kanye nobunzima benqubo yokukhipha. Njengoba izidingo zezokwelapha zikhula njalo, ukuhlinzekwa kwe-albumin ye-serum yomuntu yemvelo akuhlangabezani nezidingo zezokwelapha. Ukuvela kwe-albumin ye-serum yomuntu ephindaphindwayo kunikeze indlela ephumelelayo yokuxazulula le nkinga.
Ngokusho komuntu ophethe inkampani ye-biotechnology, basebenzise ubuchwepheshe obuthuthukisiwe bobunjiniyela bezakhi zofuzo ukuze bangenise i-serum albumin gene yomuntu kumaseli athile abambe iqhaza (njengemvubelo noma amaseli ezincelisayo) futhi bakhiqize i-recombinant human serum albumin ehlanzekile kakhulu futhi esebenza kahle ngokusebenzisa isiko lamaseli amakhulu. Lobu buchwepheshe abugcini nje ngokuthuthukisa ukusebenza kahle kokukhiqiza kodwa futhi bunciphisa kakhulu izindleko zokukhiqiza kanye nengozi yokungcoliswa yigciwane.
Ngemva kokuhlolwa okuqinile kwemitholampilo, i-albumin ye-serum yomuntu ephinde yakhiwa kulokhu ibonise imisebenzi yemvelo kanye nokuphepha okufana nokwe-albumin yemvelo ye-serum. Lokhu kusho ukuthi esikhathini esizayo, i-albumin ye-serum yomuntu ephinde yasetshenziswa ingasetshenziswa kabanzi ekwelapheni imitholampilo, njengokwelapha ama-ascites noma ukuvuvukala okubangelwa yi-cirrhosis yesibindi, i-nephrotic syndrome, i-hypoproteinemia, njll., kanye nokusetshenziselwa ukulahleka kwe-albumin okubangelwa ukusha, ukulimala, njll. Ngaphezu kwalokho, i-albumin ye-serum yomuntu ephinde yasetshenziswa ingasetshenziswa njengesandisi sevolumu ye-plasma ezimweni eziphuthumayo njengokuhlinzwa kanye nokushaqeka.
Abangaphakathi embonini baveze ukuthi ucwaningo oluphumelelayo kanye nokuthuthukiswa kwe-albumin ye-serum yomuntu ephindaphindwayo akugcini nje ngokunciphisa ukushoda kwe-albumin kodwa futhi kukhuthaza intuthuko entsha yemboni yezokwelapha. Njengoba ubuchwepheshe buqhubeka bukhula kanye nokunciphisa izindleko, i-albumin ye-serum yomuntu ephindaphindwayo kulindeleke ukuthi isetshenziswe kabanzi emhlabeni wonke esikhathini esizayo, okuzoletha izinzuzo ezigulini eziningi.
Le nkampani ye-biotechnology ithe izoqhubeka nokukhulisa ukutshalwa kwezimali ocwaningweni nasekuthuthukisweni, ikhuthaze inqubo yokuthuthukiswa kwezimboni ze-albumin ye-human recombinant, futhi ihlole ukusetshenziswa kwayo emikhakheni eminingi. Ngesikhathi esifanayo, izophinde ibambisane nezikhungo zezokwelapha zasekhaya nezangaphandle kanye nezikhungo zocwaningo ukuqinisekisa nokuthuthukisa uhlelo lokusetshenziswa kwemitholampilo lwe-albumin ye-human recombinant.
Isikhathi sokuthunyelwe: Disemba 11-2024
