I-α-Ketoglutaric Acid (α-KG)

I-α-Ketoglutaric Acid (α-KG), eyaziwa nangokuthi i-2-oxoglutaric acid, iyi-metabolite eyinhloko ephakathi emjikelezweni we-tricarboxylic acid yomuntu, kanye nezinto zokusetshenziswa zamakhemikhali nezinobuthi ezisebenza kahle neziguquguqukayo. Ibonakala njengempuphu emhlophe ecwebezelayo enezakhiwo ezizinzile ze-physicochemical kanye nendawo yokuncibilika engaguquki. Umkhiqizo uncibilika kakhulu emanzini nase-alcohols, kuyilapho cishe ungancibiliki kuma-ether. Une-extrusion esheshayo, ubumsulwa obuphezulu, okuqukethwe okungcolile okuphansi kanye nokuhambisana okuqinile. Ngaphansi kwezimo ezifanele zokugcina, izakhiwo zawo zihlala zizinzile. Ingaphenduka umbala kancane ngemva kokugcinwa isikhathi eside futhi i-hygroscopic ngokulinganisela, ihambisana ngokugcwele nezindinganiso zezinto zokusetshenziswa zezimboni, ze-biochemical, zemithi kanye nezimboni zokudla.

Njenge-reagent ebalulekile ye-biochemical, i-α-KG isebenza njengesisekelo esizinikele sokuthola i-transaminase ne-dehydrogenase, kanye ne-reagent eyisizayo ebalulekile yokuhlolwa kokusebenza kwesibindi somtholampilo. Isetshenziswa kabanzi ekuhlolweni kwelabhorethri, ekuhlaziyweni kwe-biochemical kanye nasekunqumeni i-tryptophan. Ngokunemba okuphezulu kokuthola kanye nokuqina okuhle kakhulu kokuhlola, iyinto ekhethwayo yocwaningo lwesayensi kanye nokuhlolwa kwezokwelapha. Njenge-derivative ebalulekile ye-valeric acid, ihlanganyela ezindleleni ezinkulu zomzimba ze-metabolic futhi isebenza njengomxhumanisi obalulekile ekuphenduleni okubangelwa yi-glutamate dehydrogenase, inemisebenzi emihle kakhulu yebhayoloji kanye nokuphepha okuphezulu.

Ngenxa yezakhiwo zayo eziphakeme ze-physicochemical kanye nephrofayili yokuphepha, i-α-KG isetshenziswa kabanzi njengezinto zokusetshenziswa kwemithi, izithasiselo zezempilo kanye nezengezo zokudla, kanye ne-intermediate yokwenziwa kwezinto eziphilayo. Njengoba yenziwe ngamasu okucwenga ayinkimbinkimbi, umkhiqizo wethu uhlangabezana nezidingo zobumsulwa obuqinile ngekhwalithi ehambisanayo kanye nokusebenza okuthembekile. Ifanelekela ucwaningo nokuthuthukiswa kwemithi, ukukhiqizwa kwemikhiqizo yezempilo, ukucubungula ukudla, ukwenziwa kwamakhemikhali amahle kanye nokuhlolwa kwesayensi. Ngezinzuzo zokuphepha okuphezulu, ukusebenza okuzinzile kanye nokusebenza okubanzi, isibe yinto yokusetshenziswa esezingeni eliphezulu ekhethwa kakhulu yamabhizinisi nezikhungo zocwaningo emhlabeni jikelele.