I-α-Ketoglutaric Acid (α-KG)

I-α-Ketoglutaric Acid (α-KG), ekwaziwa ngokuba yi-2-oxoglutaric acid, yi-metabolite ephakathi ephambili kumjikelo we-tricarboxylic acid yomntu, kunye ne-chemical fine and biochemical material esebenza kakuhle kwaye iguquguqukayo. Ibonakala njengomgubo omhlophe ocolekileyo wekristale oneempawu ze-physicochemical ezizinzileyo kunye nendawo yokunyibilika engaguqukiyo. Imveliso iyanyibilika kakhulu emanzini nakwii-alcohols, ngelixa iphantse inganyibiliki kwi-ethers. Inokunyibilika ngokukhawuleza, ubumsulwa obuphezulu, umxholo wokungcola okuphantsi kunye nokuhambelana okunamandla. Phantsi kweemeko ezifanelekileyo zokugcina, iimpawu zayo zihlala zizinzile. Ingajika ibe nombala kancinci emva kokugcinwa ixesha elide kwaye i-hygroscopic ephakathi, ihambelana ngokupheleleyo nemigangatho yezinto eziluhlaza kwimizi-mveliso, i-biochemical, amayeza kunye nemizi-mveliso yokutya.

Njenge-reagent ebalulekileyo ye-biochemical, i-α-KG isebenza njengesiseko esizinikeleyo sokufumanisa i-transaminase kunye ne-dehydrogenase, kunye ne-reagent encedisayo ebalulekileyo kwiimvavanyo zokusebenza kwesibindi. Isetyenziswa kakhulu kuvavanyo lwelabhoratri, uhlalutyo lwe-biochemical kunye nokumisela i-tryptophan. Ngokuchaneka okuphezulu kokufumanisa kunye nokuzinza okugqwesileyo kovavanyo, sisixhobo esikhethwayo sophando lwesayensi kunye novavanyo lweklinikhi. Njengesiphumo esibalulekileyo se-valeric acid, ithatha inxaxheba kwiindlela eziphambili zomzimba ze-metabolic kwaye isebenza njenge-intermediate ebalulekileyo kwiimpendulo ezibangelwa yi-glutamate dehydrogenase, inemisebenzi ebalaseleyo yebhayoloji kunye nokhuseleko oluphezulu.

Ngenxa yeempawu zayo eziphezulu ze-physicochemical kunye neprofayili yokhuseleko, i-α-KG isetyenziswa kakhulu njengezinto eziluhlaza kwiimveliso zamayeza, izongezo zempilo kunye nezongezo zokutya, kunye nesixhobo esiphakathi sokwenza izinto eziphilayo. Yenziwe ngeendlela zokucoca eziphucukileyo, imveliso yethu ihlangabezana neemfuno ezingqongqo zobumsulwa kunye nomgangatho ohambelanayo kunye nokusebenza okuthembekileyo. Ifanelekile kwi-R&D yamayeza, ukuveliswa kwemveliso yezempilo, ukucubungula ukutya, ukwenziwa kweekhemikhali ezintle kunye novavanyo lwesayensi. Ngeenzuzo zokhuseleko oluphezulu, ukusebenza okuzinzileyo kunye nokusetyenziswa ngokubanzi, iye yaba yinto eluhlaza ekhethwayo ephezulu kwiinkampani kunye namaziko ophando kwihlabathi liphela.