aside α-Ketoglutaric (α-KG)

Acide α-Ketoglutaric (α-KG), izwi kandi nka aside 2-oxoglutaric, ni ingenzi mu mubiri w’umuntu mu mikorere ya aside tricarboxylic, ndetse n’ibikoresho fatizo bya shimi na biochemical bifite imikorere myiza kandi ikora neza. Bigaragara nk’ifu y’umweru ifite imiterere ihamye ya fizikiki n’aho ishongesha. Iyi fu irashonga cyane mu mazi no muri alcool, mu gihe idashonga cyane muri ether. Irashonga vuba, ifite ubuziranenge bwinshi, idafite umwanda mwinshi kandi ihura neza cyane. Mu gihe kibikwa neza, imiterere yacyo iguma ihamye. Ishobora guhinduka ibara gato nyuma yo kubikwa igihe kirekire kandi ikaba ifite hygroscopic iringaniye, ikurikiza neza amabwiriza y’ibikoresho fatizo ku nganda, biochemical, farumasi n’ibiribwa.

Nk'ikintu cy'ingenzi cya biochemical reagent, α-KG ikora nk'ikintu cyihariye cyo gupima transaminase na dehydrogenase, ndetse n'ikintu cy'ingenzi gifasha mu gupima imikorere y'umwijima. Ikoreshwa cyane mu gupima muri laboratwari, gusesengura biochemical no kumenya tryptophan. Kubera ko ifite ubuhanga bwo gupima neza no kudahindagurika mu igerageza, ni igikoresho gikunzwe cyane mu bushakashatsi bwa siyansi no mu isuzuma ry'ubuvuzi. Nk'ikintu cy'ingenzi kiva muri aside valeric, igira uruhare mu nzira z'ingenzi z'imikorere y'umubiri kandi igakora nk'ikintu cy'ingenzi mu gukora ibikorwa bikururwa na glutamate dehydrogenase, ifite imikorere myiza ya biyolojiya n'umutekano mwinshi.

Kubera imiterere yayo myiza ya fizikiki n'umutekano wayo, α-KG ikoreshwa cyane nk'ibikoresho fatizo mu miti, inyongeramusaruro ku buzima n'inyongeramusaruro ku biribwa, ndetse n'uburyo bwo guhuza imikorere y'ibinyabuzima. Bikozwe mu buryo bugezweho bwo gutunganya, ibicuruzwa byacu byujuje ibisabwa byose byo mu rwego rwo hejuru kandi bifite ubwiza buhamye n'imikorere yizewe. Bikwiriye ubushakashatsi n'iterambere mu by'imiti, gukora ibicuruzwa ku buzima, gutunganya ibiribwa, gukora imiti neza no kugerageza siyansi. Bitewe n'inyungu zo kugira umutekano mwinshi, imikorere ihamye no gukoreshwa mu buryo bugari, yabaye ibikoresho fatizo byiza cyane ku bigo n'ibigo by'ubushakashatsi ku isi yose.