I-Milrinone: Inketho Entsha Yokwelashwa Kokwehluleka Kwenhliziyo

Emkhakheni wokwelashwa kwezifo zenhliziyo, ukwehluleka kwenhliziyo bekulokhu kuyinkinga enzima edonsela ukunaka okukhulu. I-Milrinone, ngokusebenza kwayo okuhle kakhulu, iletha ithemba elisha enanini elikhulu leziguli ezinenkinga yenhliziyo.

Njengomvimbeli we-phosphodiesterase osebenza kahle kakhulu, i-milrinone ithuthukisa kakhulu ukugoba kwenhliziyo futhi ikhulisa imithambo yegazi ngempumelelo ngendlela ehlukile yokusebenza. Lesi sici siyenza isebenze kahle kakhulu ekuthuthukiseni ukusebenza kwenhliziyo, inciphise ngokushesha izimpawu ezifana nokuphelelwa umoya nokukhathala ezigulini ezihluleka yinhliziyo, futhi ithuthukise kakhulu ikhwalithi yokuphila kweziguli.

Uma kuqhathaniswa nemithi yokwelapha yendabuko, i-milrinone inezinzuzo eziningi. Isebenza ngokushesha futhi ingasebenza ngesikhathi esifushane, okuvumela iziguli ukuthi zizwe ukukhululeka kwezimpawu ngokushesha. Ngaphezu kwalokho, umphumela wezokwelapha we-milrinone uhlala isikhathi eside, unikeza iziguli isiqinisekiso sokwelashwa esizinzile. Ekusetshenzisweni kwemitholampilo, i-milrinone ifakazelwe ukuthi inemiphumela ebalulekile yokwelapha ekuhlulekeni kwenhliziyo okubangelwa yizizathu ezahlukahlukene. Kungakhathaliseki ukuthi ukwehluleka kwenhliziyo okubangelwa yisifo senhliziyo esibangelwa yi-ischemic, i-cardiomyopathy, noma isifo senhliziyo se-valvular, i-milrinone ingabonisa ukusebenza kwayo okuhle.

Kwabasebenzi bezokwelapha, i-milrinone kulula ukuyisebenzisa futhi umthamo wayo kulula ukuwulungisa. Ingasetshenziswa ukwakha izinhlelo zokwelapha ezenzelwe wena ngokwezimo ezithile zeziguli. Ukuphepha kwayo kuqinisekiswe futhi yizivivinyo zemitholampilo eziqinile, futhi ukusabela okubi kuyalawuleka, okunikeza odokotela ithuba lokukhetha okuthembekile ekwelapheni ukwehluleka kwenhliziyo.

I-Milrinone ihola umkhuba omusha ekwelapheni ukwehluleka kwenhliziyo nokuvikela impilo yeziguli. Ukukhetha i-milrinone kusho ukukhetha uhlelo lokwelashwa olusezingeni eliphezulu, okuletha ithuba lokubuyisela impilo enempilo ezigulini. Masibambisane ne-milrinone ukuze sinqobe inkinga yezokwelapha yokwehluleka kwenhliziyo futhi sifake amandla amasha empilweni yeziguli.