I-Milrinone: Ukhetho Olutsha Lonyango Lokusilela Kwentliziyo

Kwicandelo lonyango lwezifo zentliziyo, ukusilela kwentliziyo bekusoloko kuyingxaki enzima etsala ingqalelo enkulu. I-Milrinone, ngenxa yokusebenza kwayo okugqwesileyo, izisa ithemba elitsha kwinani elikhulu lezigulana ezinengxaki yentliziyo.

Njengesithinteli se-phosphodiesterase esisebenza kakuhle kakhulu, i-milrinone iphucula kakhulu ukuqiniswa kwentliziyo kwaye iyandisa ngokufanelekileyo imithambo yegazi ngendlela eyahlukileyo yokusebenza. Olu phawu luyenza isebenze kakuhle kakhulu ekuphuculeni ukusebenza kwentliziyo, inciphise ngokukhawuleza iimpawu ezifana nokuphelelwa ngamandla kunye nokudinwa kwizigulana ezinesifo sentliziyo, kwaye iphucule kakhulu umgangatho wobomi bezigulana.

Xa kuthelekiswa namayeza esintu okunyanga, i-milrinone ineengenelo ezininzi. Isebenza ngokukhawuleza kwaye ingasebenza ngexesha elifutshane, ivumela izigulane ukuba zive ukukhululeka kweempawu ngokukhawuleza. Ngaphezu koko, isiphumo sonyango se-milrinone sihlala ixesha elide, sibonelela izigulane ngesiqinisekiso sonyango esizinzileyo. Kwizicelo zonyango, i-milrinone ibonakalisiwe ukuba inemiphumo emihle yokunyanga ukusilela kwentliziyo okubangelwa zizizathu ezahlukeneyo. Nokuba kukusilela kwentliziyo okubangelwa sisifo sentliziyo esibangelwa yi-ischemic, i-cardiomyopathy, okanye isifo sentliziyo se-valvular, i-milrinone inokubonisa ukusebenza kwayo okukhulu.

Kwabasebenzi bezonyango, i-milrinone kulula ukuyisebenzisa kwaye idosi ilula ukuyilungisa. Ingasetyenziselwa ukwenza izicwangciso zonyango ezenzelwe wena ngokweemeko ezithile zezigulana. Ukhuseleko lwayo lukwaqinisekiswe zizilingo ezingqongqo zeklinikhi, kwaye iimpendulo ezingalunganga ziyalawuleka, nto leyo enika oogqirha ukhetho oluthembekileyo kunyango lokusilela kwentliziyo.

I-Milrinone ikhokela umkhwa omtsha kunyango lokusilela kwentliziyo kunye nokukhusela impilo yezigulana. Ukukhetha i-milrinone kuthetha ukukhetha isicwangciso sonyango esisemgangathweni ongcono, esizisa ithuba lokubuyisela ubomi obusempilweni kwizigulana. Masibambisane ne-milrinone ukuze soyise ingxaki yezonyango yokusilela kwentliziyo kunye nokufaka amandla amatsha kubomi bezigulana.