α-Ketoglutaric Acid (α-KG)

α-Ketoglutaric Acid (α-KG), inozivikanwawo se2-oxoglutaric acid, inhengo yepakati pemetabolite muchikamu che tricarboxylic acid chemunhu, pamwe chete nechinhu chakagadzirwa nemakemikari akanaka uye chebiochemical. Chinotaridzika seupfu hwakachena hwakatsetseka hwekristaro hune hunhu hwakagadzikana hwefizikisi uye nzvimbo yakanyunguduka isingachinji. Chigadzirwa ichi chinonyunguduka zvakanyanya mumvura nealcohols, ukuwo chisinganyunguduke mu ethers. Chine kunyunguduka nekukurumidza, kuchena kwakanyanya, kusvibiswa kwakaderera uye kuenderana kwakasimba. Pasi pemamiriro ezvinhu akakodzera ekuchengetedza, hunhu hwacho hunoramba hwakagadzikana. Chinogona kuchinja ruvara zvishoma mushure mekuchengetwa kwenguva refu uye chine hygroscopic iri pakati nepakati, chichitevedzera zvizere mitemo yezvinhu zvemaindasitiri, biochemical, mishonga uye chikafu.

Sechinhu chakakosha chebiochemical reagent, α-KG inoshanda senzvimbo yakatsaurirwa yekuona transaminase ne dehydrogenase, uye senzira inobatsira yekuyedza mashandiro echiropa. Inoshandiswa zvakanyanya mukuyedza murabhoritari, kuongorora biochemical uye kuona tryptophan. Nekunyatsoongorora kwakakodzera uye kugadzikana kwakanaka kwekuyedza, chinhu chinodiwa pakutsvagisa kwesainzi uye kuyedza kwekiriniki. Sechinhu chakakosha chinobva mu valeric acid, inobata mabasa makuru emuviri uye inoshanda senzira yakakosha yepakati mukuita kwemaitiro kunokonzerwa ne glutamate dehydrogenase, iine basa rakanaka rehupenyu uye yakachengeteka zvakanyanya.

Nekuda kwehunhu hwayo hwepamusoro hwe physicochemical uye kuchengetedzeka kwayo, α-KG inoshandiswa zvakanyanya sezvinhu zvekugadzira mishonga, zvekudya zvinovaka muviri uye zvekudya, pamwe chete nechinhu chinoshandiswa pakugadzira organic. Yakagadzirwa nenzira dzekugadzirisa dzakaoma, chigadzirwa chedu chinosangana nezvinodiwa zvekuchena kwakasimba uye hunhu hwakasimba uye mashandiro akavimbika. Yakakodzera mukuongorora nekuvandudza mishonga, kugadzira zvigadzirwa zvehutano, kugadzira chikafu, kugadzira makemikari akanaka uye kuyedza kwesainzi. Nekubatsirwa kwekuchengetedzeka kwakanyanya, kushanda kwakasimba uye kushanda kwakafara, yave chinhu chemhando yepamusoro chemakambani nemasangano ekutsvagisa pasi rese.