Equol/(±)-Equol/CAS:94105-90-5/531-95-3
Short Description:
Product Name: Equol
CAS: 94105-90-5/531-95-3
Type: ZA-Y
MF:C15H14O3
MW:242.27
STRUCTURE:
Description:
Equol is a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERβ while the (R)-enantiomer demonstrates greater affinity towards ERα. Synthesized as a racemic mixture, (±)-equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM.
Specification:
| Item | Specification |
| Melting point | 158-160 °C |
| Boiling point | 441.7±45.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| pKa | 9.94±0.40(Predicted) |
| Solubility | soluble in Ethanol |
| Storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| Form | Crystalline powder |
| Color | White to Light yellow to Light red |
Usage
(±)-Equol is a human urinary metabolite of the soy isoflavones Daidzein (D103500).
(±)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.
A human urinary metabolite of Daidzein. It is also a natural estrogenic metabolite from soy isoflavones.
(±)-Equol is a metabolite produced in vivo from the soy phytoestrogen daidzein by the action of certain gut microflora, and is a nonsteroidal estrogen of the isoflavonoid class. (±)-Equo has been reported to have estrogenic activity and affinity for estrogen receptors. (±)-Equo can exist in two enantiomeric forms, (S)-equol and (R)-equol. In binding assays, (S)-equol has a higher binding affinity for estrogen β receptors.
Packaging and Shipping
25KG/Drum or as customer requirements.
Belongs to common goods and can deliver by ocean and air
Keep and storage
Shelf life:24 month from date of manufacture in original unopened packaging stored in a cool dry place out of direct sunlight, water.
Ventilated warehouse, Low temperature drying, Separated from oxidants, acids.
