Insimu Ngo-Agasti 2024, ngokuthuthukiswa kokuqwashisa ngezempilo emhlabeni jikelele, imakethe yamagciwane iye yamukela amathuba amasha okuthuthukiswa. Phakathi kwawo, i-benzalkonium chloride, njengesibulali-magciwane esisebenza kahle kakhulu futhi esibanzi, iye yadonsela ukunaka okukhulu ngenxa yezinzuzo zayo eziyingqayizivele.
1. I-Benzalkonium chloride uhlobo lwesibulali-magciwane se-ammonium salt esine-chain eyodwa. Ngezici zayo ezifana nokuzinza okuhle, ukungabi nobuthi, kanye nokungacasuli, isibe yindawo yokucwaninga eminyakeni yamuva nje. Ayikwazi ukubulala amabhaktheriya nesikhunta ngempumelelo kuphela kodwa futhi ivimbela amagciwane, futhi isetshenziswa kabanzi emikhakheni efana nokubulala amagciwane esikhumbeni kanye nemvelo. Njengamanje, i-benzalkonium chloride ivunyelwe yi-National Medical Products Administration (NMPA) ukuthi isetshenziswe kumalungiselelo ahlukahlukene afana nama-patches, izixazululo, ama-spray, namaconsi amehlo.
2. Indlela yokubulala amagciwane ye-benzalkonium chloride igxile kakhulu ekushintsheni ukungena kwe-cytoplasmic membrane, okubangela ukuphuma kwezinto ze-cytoplasmic zamabhaktheriya, ngaleyo ndlela kuvimbele ukusebenza kwawo futhi kudlale indima yokubulala. Nakuba inomphumela onamandla kumabhaktheriya ane-Gram kanye nomphumela obuthakathaka kumabhaktheriya ane-Gram-negative njenge-Pseudomonas aeruginosa, empeleni ayisebenzi ngokumelene nesifo sofuba se-Mycobacterium kanye ne-spores yamabhaktheriya. Kodwa-ke, ekusetshenzisweni okungokoqobo, i-benzalkonium chloride isasebenza kahle kakhulu. Ikakhulukazi, isici sokuthi umphumela wayo uncishiswa kakhulu lapho kukhona igazi, ukotini, i-cellulose, nezinto eziphilayo senza ukusetshenziswa kwayo kuphephe kakhulu ngezikhathi ezithile.
3. Ngaphandle kokusetshenziswa kwayo emkhakheni wezokwelapha, i-benzalkonium chloride isetshenziswa kabanzi ekuhlanzeni amagciwane ezimbonini. Njenge-fungicide engakhiqizi i-oxidation, ingalawula ngempumelelo ukukhiqizwa kwamagciwane kanye nolwelwe kanye nokukhula kwe-slime emanzini, futhi inomphumela omuhle wokususa i-slime kanye nemiphumela ethile yokuhlakazeka nokungena. I-Benzalkonium chloride idlala indima ebalulekile emikhakheni efana namanzi okupholisa ajikeleza efektri, amanzi esitshalo sikagesi, imishini yamaphepha, kanye nezinhlelo zokujova imigodi ye-oyela.
Ngokuthuthuka kwesayensi nobuchwepheshe kanye nokwanda okuqhubekayo kwesidingo sabantu sokuhlanzeka, amathuba emakethe e-benzalkonium chloride azoba maningi nakakhulu. Izinzuzo zayo eziyingqayizivele kanye nezici zayo eziningi zenza kube ngumdlali ophelele emkhakheni wokubulala amagciwane, okunikela ngamandla abalulekile ekuthuthukisweni kwezinkampani zezempilo zomhlaba wonke.
Isikhathi sokuthunyelwe: Novemba-20-2024
