Sodium thiomethoxide/Sodium methanethiolate/CAS:5188-07-8
Short Description:
Product Name: Sodium thiomethoxide
CAS: 5188-07-8
Type: ZA-Y
MF:CH3NaS
MW:70.09
STRUCTURE:
Description:
Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.
Specification:
| Item | Specification |
| Density | 1.12[at 20℃] |
| Vapor pressure | 29hPa at 25℃ |
| Fp | 27°C |
| Storage temp. | Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture. |
| Solubility | Soluble in Water |
| Form | Liquid |
| Color | Colorless transparent liquid |
Usage
Sodium thiomethoxide is a strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.
Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.
Packaging
200KG/Drum or as customer requirements.
Keep and storage
Shelf life:24 month from date of manufacture in original unopened packaging stored in a cool dry place out of direct sunlight, water.
Ventilated warehouse, Low temperature drying, Separated from oxidants, acids.
