Nicotinamide/CAS:98-92-0
Short Description:
Product name:Nicotinamide
Type:ZA-N
CAS:98-92-0
MF:C6H6N2O
MW: 122.12
STRUCTURE:
Density: 1.40
melting point: 182 °C
Niacinamide is a white needle-like crystal or crystalline powder, odorless or slightly odorous, with a slightly bitter taste. Its relative density is 1.4, and its melting point is 129-131℃. 1g of this product can be dissolved in 1mL of water, 1.5mL of ethanol, or 10mL of glycerol, but not in ether. The pH of a 10% aqueous solution is 6.5-7.5. It has weak hygroscopicity. It is relatively stable, resistant to acids, alkalis, and high temperatures. It is stable to light and heat in dry air, but when heated in alkaline or acidic solutions, it forms nicotinic acid. The oral LD50 in rats is 2.5-3.5g/kg, and the ADI value is not specifically specified (ECC, 1990).
specification
|
ITEMS |
SPECIFICATIONS |
TEST RESULT |
|
Appearance |
White crystalline powder |
Complies |
|
Solubility |
Free soluble in water and in anhydrous ethanol,slightly soluble in methylene chloride |
Complies |
|
Idntification |
A:Infrared absorption |
Complies |
|
B:Ultraviolet absorption.the A245/A262 ratio is 0.63-0.67 |
0.66 |
|
|
C.Thin-layer chromatogrzphy |
Complies |
|
|
Assay(%) |
99.0~101.0 |
100.1 |
|
Melting range(□) |
128~131 |
128.7-130.2 |
|
Appearance of solution |
Not more intensely coloured than reference solution BY7 |
Complies |
|
PH |
6.0~7.5 |
6.86 |
|
Relzted substances |
Test as per EP10.0 |
Complies |
|
Readily carbonizable substances |
The sample solution has no more colo than matching fluidA |
Complies |
|
Loss on drying(%) |
20.5 |
0.03 |
|
Sulfated ash(%) |
20.1 |
0.0 |
|
Residue on igmition(%) |
≤0.1 |
0.0 |
|
Heavy metals(mglkg) |
≤20 |
-20 |
|
CONCLUSION |
QUALIFIED(Comply with USP2022 and EP10.0standard) | |
Usage
- Moisturizing, oil control, and reducing blackheads: Niacinamide can effectively reduce transepidermal water loss. Although its effect when used alone is not as good as that of hyaluronic acid and glycerin, the effect when used in combination is definitely 1+1>2; niacinamide can calm the "overactive" sebaceous glands, thereby achieving oil control and reducing blackheads and acne.
- Good anti-wrinkle ability: The anti-wrinkle ability of niacinamide lies in its ability to activate ATP, provide vitality to keratinocytes, increase collagen synthesis, and it has good synergistic ability, which can be used together with other anti-wrinkle ingredients.
- Good auxiliary sun protection effect: The damage caused by ultraviolet rays to the human body is not only tanning, but also immune suppression (Chemicalbook) and even skin cancer. Many studies at home and abroad have shown that niacinamide can effectively reduce the occurrence of skin photoimmunosuppression during ultraviolet irradiation.
- Good mildness: Compared with ingredients such as vitamin C and resorcinol derivatives, niacinamide is quite mild and can be used by people with many skin types. However, attention should still be paid to skin tolerance. For example, The Ordinary Whitening Essence with a 10% niacinamide concentration still has certain irritation. Therefore, it is best to conduct a skin tolerance test before use. Only use it after confirming tolerance, and at the same time, be careful not to use it with acid-containing products such as salicylic acid and fruit acid to prevent excessive irritation to the skin.
An amide derivative of vitamin B3 and PARP inhibitor
Vitamin drugs participate in metabolic processes in the body and are used to prevent and treat pellagra and other niacin deficiency diseases.
Niacinamide has better water solubility than niacin, but it easily forms complexes with vitamin C and clumps. The dosage is 30-80mg/kg. When used in skin care products, it can prevent rough skin, maintain the health of skin cells, and promote skin whitening. When used in hair care, it can promote blood circulation in the scalp, keep hair follicles healthy, promote hair growth, and prevent hair loss.
Packaging and Shipping
25KG/Drum or as customer requirements.
Belongs to common goods and can deliver by ocean and air
Keep and storage
Shelf life:24 month from date of manufacture in original unopened packaging stored in a cool dry place out of direct sunlight, water.
Ventilated warehouse, Low temperature drying, Separated from oxidants, acids.
